Heat shock protein 90 (HSP90) activators are compounds that play a pivotal role in cellular stress response. These molecules enhance the chaperone function of HSP90, a key protein in maintaining cellular protein homeostasis during stressful conditions. By aiding proper protein folding, stabilization, and degradation, HSP90 activators contribute to cell health and have potential applications in cancer therapy, as cancer cells often rely heavily on HSP90 for their survival.