Estrogen and progestogen receptor agonists are compounds that activate estrogen and progestogen receptors, essential components of the female reproductive system. These agonists are widely used in hormone replacement therapy (HRT) for menopausal women, as they help restore hormonal balance, relieving symptoms like hot flashes and osteoporosis. They are also employed in contraceptives, endometriosis treatment, and addressing hormonal imbalances. While offering these therapeutic benefits, their use requires careful monitoring, as they can have side effects and long-term health implications.