Endothelin receptor antagonists are vital in regulating blood vessel constriction. By blocking the effects of endothelin, a potent vasoconstrictor, these medications help dilate blood vessels, reducing strain on the heart. This class of drugs is employed in the treatment of pulmonary hypertension and other cardiovascular conditions. By countering endothelin's impact, they improve blood flow and reduce the workload on the heart, enhancing patients' quality of life.