CXCR antagonists, also known as CXC chemokine receptor antagonists, play a pivotal role in modulating immune responses. These compounds target the CXCR receptors, which are key players in immune cell recruitment and inflammation. By blocking CXCR, these drugs can suppress excessive immune reactions, making them promising candidates for managing inflammatory conditions like rheumatoid arthritis and inflammatory bowel disease. Their ability to fine-tune immune responses without completely shutting them down makes them valuable tools in immunomodulation.