OX receptor antagonists are compounds designed to block the actions of orexins, neuropeptides that play a crucial role in regulating wakefulness, sleep, and appetite. By inhibiting orexin receptors, these antagonists have the potential to treat sleep disorders such as insomnia and hypersomnia. Furthermore, they might offer solutions for managing obesity by reducing excessive appetite. OX receptor antagonists continue to be a subject of interest in the pharmaceutical industry, with ongoing research into their potential therapeutic applications for sleep and metabolic disorders.