CGRP, or Calcitonin Gene-Related Peptide, plays a significant role in migraines, causing blood vessel dilation and pain. CGRP receptor antagonists are a groundbreaking class of medications designed to prevent and treat migraines. By blocking CGRP receptors, these drugs reduce blood vessel dilation and inflammation in the brain, providing relief for migraine sufferers. The advent of CGRP receptor antagonists represents a major step forward in managing this debilitating condition, offering hope to those who have long sought effective migraine treatments.