Transforming Growth Factor-beta (TGF-beta) is a critical signaling pathway involved in various cellular processes, including cell growth, differentiation, and tissue repair. TGF-beta/Smad activators are compounds designed to enhance this pathway's activity. They have potential applications in promoting tissue regeneration, regulating immune responses, and potentially treating conditions such as fibrosis or cancer. By fine-tuning TGF-beta/Smad signaling, these activators may open new avenues for therapeutic interventions.