1-(4-Amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one
[CAS# 137977-97-0]

Identification

• Classification: Organic raw materials >> Ketone compound
• Name: 1-(4-Amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one
• Molecular Formula: C₁₈H₁₇ClN₂O₂
• Molecular Weight: 328.79
• CAS Registry Number: 137977-97-0
• SMILES: CC1=C(C=CC(=C1)N)C(=O)N2CCCC(=O)C3=C2C=CC(=C3)Cl

Properties

• Density: 1.320

Safety Data

• Hazard Symbols: GHS07 Warning
• Hazard Statements: H302-H312-H332
• Precautionary Statements: P280

Discovory and Applicatios

1-(4-Amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one is a synthetic compound identified during research aimed at developing novel benzazepine derivatives with potential therapeutic applications. This compound emerged from studies focused on modifying the benzazepine core to enhance its biological activity and therapeutic potential. Researchers employed structure-activity relationship (SAR) analyses to introduce the 4-amino-2-methylbenzoyl and 7-chloro groups into the tetrahydro-5H-1-benzazepin-5-one framework. These modifications aimed to improve its pharmacokinetic properties and target specificity. The discovery of this compound represents a significant advancement in designing benzazepine-based molecules, offering a new scaffold for drug development and biomedical research.

The benzazepine core structure of the compound suggests potential use in developing antipsychotic drugs. It may interact with dopamine or serotonin receptors in the brain, providing therapeutic benefits in managing psychiatric disorders such as schizophrenia and bipolar disorder. Its ability to modulate neurotransmitter pathways could help alleviate symptoms like hallucinations, delusions, and mood disturbances. The compound's interaction with neurotransmitter systems also indicates potential as an antidepressant. It may help in the development of new treatments for depression and anxiety disorders by enhancing mood regulation and reducing symptoms of these conditions. It can be explored for treating other neurological conditions, such as epilepsy or Parkinson's disease, where modulation of neural pathways is crucial. Its unique structure could offer benefits in neuroprotection and symptom management.

In biomedical research, the compound can be used to study receptor-ligand interactions, particularly those involving dopamine and serotonin receptors. Understanding its binding affinity and selectivity can provide insights into receptor function and aid in developing receptor-specific drugs. Researching this compound can reveal its mechanism of action in modulating cellular signaling pathways. Such studies contribute to understanding how benzazepine derivatives exert their effects at the molecular level, informing the design of more effective and targeted therapies. As a lead compound, it serves as a basis for developing analogs with improved efficacy and reduced side effects. Its structure provides a starting point for designing new molecules that can be screened for various biological activities in drug discovery programs.

The compound can be used as an intermediate in organic synthesis for creating complex benzazepine derivatives. Its functional groups allow for various chemical modifications, facilitating the synthesis of diverse compounds for research and development. Its unique structural features make it a candidate for exploring applications in material sciences. Derivatives of this compound could be investigated for developing materials with specific electronic or optical properties, contributing to advancements in fields like electronics and photonics.

Similar to its potential in human medicine, the compound may be explored for treating psychiatric and neurological disorders in animals. Its applications could extend to veterinary therapeutics, providing new options for managing animal behavior and neurological conditions.

The compound can progress to clinical trials to evaluate its safety and efficacy in treating various conditions. These trials can establish dosing regimens, identify therapeutic indications, and assess potential side effects, guiding its development as a pharmaceutical agent. It may be used in combination with other drugs to enhance therapeutic outcomes. Its complementary effects on neurotransmitter pathways can be leveraged to develop combination therapies for complex conditions requiring multifaceted treatment approaches.