7-Chloro-1,2,3,4-tetrahydro-1-(2-methyl-4-nitrobenzoyl)-5H-1-benzazepin-5-one
[CAS# 137982-91-3]

Identification

• Classification: Organic raw materials >> Ketone compound
• Name: 7-Chloro-1,2,3,4-tetrahydro-1-(2-methyl-4-nitrobenzoyl)-5H-1-benzazepin-5-one
• Molecular Formula: C₁₈H₁₅ClN₂O₄
• Molecular Weight: 358.78
• CAS Registry Number: 137982-91-3
• SMILES: CC1=C(C=CC(=C1)[N+](=O)[O-])C(=O)N2CCCC(=O)C3=C2C=CC(=C3)Cl

Properties

• Density: 1.387

Safety Data

• Hazard Symbols: GHS07 Warning
• Hazard Statements: H302-H315-H319-H335
• Precautionary Statements: P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501

Discovory and Applicatios

7-Chloro-1,2,3,4-tetrahydro-1-(2-methyl-4-nitrobenzoyl)-5H-1-benzazepin-5-one was discovered during the exploration of benzazepine derivatives aimed at developing new pharmacologically active compounds. Researchers synthesized this compound by combining a benzazepine core with a 2-methyl-4-nitrobenzoyl group and a chlorine substituent at the 7th position. This synthesis aimed to enhance the biological activity and target specificity of the benzazepine framework. The discovery process involved structure-activity relationship (SAR) studies to optimize its pharmacological properties, potentially offering new therapeutic applications, particularly in targeting central nervous system (CNS) disorders and modulating receptor functions.

This compound shows potential as a candidate for antipsychotic drug development. The benzazepine structure, combined with the 2-methyl-4-nitrobenzoyl group, suggests it could interact with CNS receptors involved in psychotic disorders. It might help manage conditions like schizophrenia and bipolar disorder by modulating dopamine and serotonin pathways, contributing to symptom relief such as reducing hallucinations and stabilizing mood.The compound's ability to interact with neurotransmitter receptors also positions it as a potential antidepressant. By influencing serotonin and norepinephrine levels, it could provide therapeutic benefits for depression and anxiety disorders, offering an alternative treatment option with a unique mechanism of action compared to traditional antidepressants. It may be explored for treating neurological conditions such as epilepsy or Parkinson's disease, where modulation of neural activity is essential. Its structural properties could contribute to developing drugs that provide neuroprotection or alleviate symptoms associated with these disorders.

The compound can be utilized in research to study its effects on CNS receptors. Understanding how it binds and modulates receptor activity provides insights into neurotransmission and receptor functions, aiding in the development of receptor-targeted therapies. Researching this compound helps elucidate the mechanisms underlying its pharmacological effects. Studying its interaction with cellular targets can reveal how benzazepine derivatives exert therapeutic actions, contributing to the broader field of drug discovery. It serves as a valuable lead compound in drug discovery programs. Its structure provides a foundation for synthesizing analogs with optimized properties, facilitating the identification of new drugs with enhanced efficacy and reduced side effects.

The compound can act as an intermediate in the synthesis of other complex benzazepine derivatives. Its functional groups allow for various chemical modifications, enabling the creation of novel molecules for research and industrial applications.Derivatives of this compound may be explored in material science for developing new materials with specific electronic or optical properties. Its unique chemical structure could contribute to innovations in fields like electronics, photonics, and sensor technology.

The compound is suitable for preclinical studies to assess its efficacy and safety in animal models. These studies can provide essential data on its pharmacokinetics, pharmacodynamics, and therapeutic potential, guiding its progression to clinical trials. It may be used in combination with other drugs to enhance therapeutic outcomes. Its distinct mechanism of action could complement existing treatments, offering a multifaceted approach to managing complex conditions.

Similar to its potential in human medicine, the compound can be explored for treating CNS disorders in animals. Its applications in veterinary medicine could address behavioral and neurological conditions in livestock and companion animals.