6-Amino-4-(cyclopropylamino)nicotinonitrile
[CAS# 2159845-82-4]

Identification

• Classification: Organic raw materials >> Nitrile compound
• Name: 6-Amino-4-(cyclopropylamino)nicotinonitrile
• Molecular Formula: C₉H₁₀N₄
• Molecular Weight: 174.21
• CAS Registry Number: 2159845-82-4
• SMILES: C1CC1NC2=CC(=NC=C2C#N)N

Discovory and Applicatios

6-Amino-4-(cyclopropylamino)nicotinonitrile is a chemical compound that has gained attention in the field of medicinal chemistry due to its unique molecular structure and potential applications in drug development. This compound consists of a nicotinonitrile backbone with an amino group and a cyclopropylamino group attached at specific positions. The presence of these functional groups suggests that the molecule may possess biological activity, particularly in areas related to receptor modulation, enzyme inhibition, and potentially in the treatment of neurological disorders.

The discovery of 6-amino-4-(cyclopropylamino)nicotinonitrile emerged from the ongoing search for novel bioactive molecules that could interact with a range of biological targets. Nicotinonitriles are a class of compounds known for their ability to bind to receptors or enzymes and modulate their activity, which makes them attractive candidates for drug discovery. In particular, the inclusion of the amino group and the cyclopropylamino group could confer specific properties that might enhance the compound's ability to interact with various targets in the body.

One of the primary areas of interest in the research surrounding 6-amino-4-(cyclopropylamino)nicotinonitrile is its potential as a receptor modulator. The nicotinonitrile core is structurally related to nicotinic compounds, which have been studied extensively for their effects on neurotransmitter systems, especially in the brain. This suggests that 6-amino-4-(cyclopropylamino)nicotinonitrile could have activity at nicotinic receptors or other related targets, which could be useful for treating conditions such as Alzheimer's disease, Parkinson's disease, and other neurological disorders. The cyclopropylamino group may also influence the compound's ability to cross the blood-brain barrier, making it more likely to be effective in treating central nervous system disorders.

Another important area of application for 6-amino-4-(cyclopropylamino)nicotinonitrile is in enzyme inhibition. Many biologically active compounds are developed as enzyme inhibitors to modulate the activity of enzymes involved in disease pathways. The amino and nitrile groups in the structure of 6-amino-4-(cyclopropylamino)nicotinonitrile suggest that the molecule may be capable of binding to enzyme active sites, potentially interfering with key biological processes. This could be particularly relevant in the treatment of diseases involving abnormal enzyme activity, such as cancer, metabolic disorders, or inflammatory conditions.

Furthermore, the compound's relatively simple structure and potential for modification make it a versatile scaffold for the design of new molecules with enhanced potency or selectivity for specific targets. Researchers can modify the cyclopropylamino group or the nitrile group to improve the compound's pharmacokinetic properties, such as its stability, solubility, and bioavailability, which are critical factors in drug development.

In summary, 6-amino-4-(cyclopropylamino)nicotinonitrile is a promising chemical compound with potential applications in the treatment of neurological and metabolic disorders. Its ability to interact with receptors and enzymes suggests that it could be developed into a therapeutic agent for a variety of diseases. Ongoing research into the compound's biological activity and its potential to modulate specific biological pathways will be essential in determining its clinical applicability.