Enlicitide chloride
[CAS# 2407527-16-4]

Identification

• Classification: API >> Antineoplastic agents
• Name: Enlicitide chloride
• Synonyms: [6-[[(11S,17S,20S,23S,27S,39S,42S,63S,66R)-47-fluoro-20-[(1R)-1-hydroxyethyl]-17-[(4-methoxyphenyl)methyl]-11,63-dimethyl-10,16,19,22,30,40,58,61,64,67,70-undecaoxo-28-oxa-1,9,15,18,21,24,31,41,51,62,65,68-dodecazanonacyclo[37.18.11.23,6.124,42.133,37.144,51.011,15.023,27.045,50]triheptaconta-3(73),4,6(72),33,35,37(71),44(69),45(50),46,48-decaen-66-yl]methylamino]-6-oxohexyl]-trimethylazanium;chloride
• Molecular Formula: C₈₂H₁₁₀ClFN₁₄O₁₅
• Molecular Weight: 1586.29
• CAS Registry Number: 2407527-16-4
• SMILES: C[C@H]1C(=O)N[C@@H](C(=O)N[C@H]2CC3=CC(=CC=C3)CNC(=O)CO[C@H]4CCN5[C@@H]4C(=O)N[C@H](C(=O)N[C@H](C(=O)N6CCC[C@]6(C(=O)NCCC7=CC=C(CN(CCCCCCN8C=C(C[C@@H](C5=O)NC2=O)C9=C8C=CC(=C9)F)C(=O)CCC(=O)N1)C=C7)C)CC1=CC=C(C=C1)OC)[C@@H](C)O)CNC(=O)CCCCC[N+](C)(C)C.[Cl-]

Discovory and Applicatios

Enlicitide chloride is a synthetic peptide compound primarily explored for its potential in therapeutic applications, particularly in modulating immune responses and acting as an antagonist to certain receptors. Peptides like enlicitide chloride are composed of short chains of amino acids and have garnered interest due to their specificity and reduced side effects compared to small molecule drugs. The chloride form of the compound enhances its solubility, making it suitable for various biochemical and pharmacological studies.

The discovery of enlicitide chloride is rooted in research aimed at developing peptide-based therapies that can interact with protein-protein interactions, which are difficult to target with traditional small molecule drugs. Peptides are known for their high specificity to biological targets, which makes them ideal candidates for drug development in areas such as oncology, immunology, and metabolic disorders. The structure of enlicitide chloride, which includes key amino acid residues, is designed to bind selectively to certain biological receptors, modulating their activity to achieve a therapeutic effect.

One of the main applications of enlicitide chloride is in the field of immune modulation. By acting on specific receptors, this peptide has the potential to either suppress or enhance immune responses, making it a candidate for treating autoimmune diseases or enhancing immune activity in cancer therapy. Additionally, its high specificity reduces the likelihood of off-target effects, making it a promising compound for further investigation in preclinical and clinical trials.

In research and development, enlicitide chloride has been studied as a tool for understanding receptor-ligand interactions. Its ability to selectively bind and influence receptor activity makes it useful in mapping signaling pathways and identifying potential drug targets. This has made it a valuable asset in both academic and pharmaceutical research, where understanding the detailed mechanisms of action can lead to the development of more effective therapies.

Peptide-based drugs, like enlicitide chloride, offer advantages in terms of biocompatibility and reduced toxicity compared to traditional drugs. However, challenges such as peptide stability and bioavailability remain key areas of research. As a result, enlicitide chloride continues to be an important focus in the search for novel therapeutic agents that can provide targeted, effective treatments with minimal side effects.