5,6-Diethyl-2,3-dihydro-1H-inden-2-amine hydrochloride
[CAS# 312753-53-0]

Identification

• Classification: Chemical reagent >> Organic reagent >> Amine salt (ammonium salt)
• Name: 5,6-Diethyl-2,3-dihydro-1H-inden-2-amine hydrochloride
• Molecular Formula: C₁₃H₁₉N^.HCl
• Molecular Weight: 225.76
• CAS Registry Number: 312753-53-0
• EC Number: 691-331-5
• SMILES: CCC1=C(C=C2CC(CC2=C1)N)CC.Cl

Properties

• Melting point: >250 ºC

Safety Data

• Hazard Symbols: GHS05;GHS07;GHS09 Danger
• Hazard Statements: H302-H312-H315-H317-H318-H319-H332-H335-H411
• Precautionary Statements: P261-P264-P264+P265-P270-P271-P272-P273-P280-P301+P317-P302+P352-P304+P340-P305+P351+P338-P305+P354+P338-P317-P319-P321-P330-P332+P317-P333+P317-P337+P317-P362+P364-P391-P403+P233-P405-P501

Hazard Classification

Hazard	Class	Category Code	Hazard Statement
Acute toxicity	Acute Tox.	4	H302
Skin irritation	Skin Irrit.	2	H315
Acute toxicity	Acute Tox.	4	H332
Eye irritation	Eye Irrit.	2	H319
Acute toxicity	Acute Tox.	4	H312
Specific target organ toxicity - single exposure	STOT SE	3	H335
Chronic hazardous to the aquatic environment	Aquatic Chronic	2	H411
Skin sensitization	Skin Sens.	1	H317
Serious eye damage	Eye Dam.	1	H318

Discovory and Applicatios

5,6-Diethyl-2,3-dihydro-1H-inden-2-amine hydrochloride is an organic chemical compound that has attracted attention due to its unique structure and potential applications in medicinal chemistry. The compound belongs to a class of indene derivatives, which are aromatic compounds that contain a bicyclic structure with a fused benzene ring and cyclopropene. This specific derivative contains two ethyl groups attached to the indene core, as well as an amine group, which is a key functional group in many biologically active molecules.

The discovery of 5,6-Diethyl-2,3-dihydro-1H-inden-2-amine hydrochloride is part of ongoing research aimed at exploring novel compounds with therapeutic potential. The indene backbone and amine group in the structure make it a versatile candidate for the development of pharmacologically active molecules. The presence of the diethyl substitution at positions 5 and 6 of the indene ring may influence the compound’s physicochemical properties, such as its solubility, lipophilicity, and receptor binding profile.

5,6-Diethyl-2,3-dihydro-1H-inden-2-amine hydrochloride may find applications in a variety of therapeutic areas, including neurology and psychiatry. The amine group is a common feature of compounds that interact with neurotransmitter systems, particularly those involving monoamine neurotransmitters such as serotonin, dopamine, and norepinephrine. These neurotransmitters are implicated in various neurological and psychiatric conditions, including depression, anxiety, and schizophrenia. Compounds with amine groups have been shown to modulate the activity of receptors or enzymes associated with neurotransmitter systems, making them useful in drug development.

The compound’s potential as a central nervous system (CNS) agent may stem from its ability to interact with specific receptors or transporters involved in neurotransmission. For example, the amine group in 5,6-Diethyl-2,3-dihydro-1H-inden-2-amine hydrochloride may enable it to function as a partial agonist or antagonist at certain receptors, modulating neurotransmitter release and uptake. Additionally, the indene ring structure could influence the compound’s ability to cross the blood-brain barrier, an essential factor for the development of CNS-active drugs.

The hydrochloride salt form of 5,6-Diethyl-2,3-dihydro-1H-inden-2-amine enhances the compound’s solubility and stability, making it more suitable for formulation into oral or injectable drug preparations. As a hydrochloride salt, it is more likely to exhibit better pharmacokinetic properties, including improved bioavailability and absorption.

In addition to its potential therapeutic applications, 5,6-Diethyl-2,3-dihydro-1H-inden-2-amine hydrochloride may be of interest to researchers studying the synthesis of novel indene-based molecules. The compound can serve as a building block in the design of more complex structures with targeted pharmacological profiles. By modifying the substituents on the indene ring or the amine group, researchers may be able to optimize the compound’s activity against specific targets, such as serotonin or dopamine receptors, leading to the development of new drugs for the treatment of various neurological disorders.

In summary, 5,6-Diethyl-2,3-dihydro-1H-inden-2-amine hydrochloride is a promising chemical compound with potential applications in the development of drugs targeting the central nervous system. Its unique structure, with an indene ring and amine group, offers various possibilities for modulating neurotransmitter systems and treating conditions such as depression, anxiety, and schizophrenia. Future research into the pharmacological properties and therapeutic potential of this compound could lead to the development of new, effective treatments for a range of neurological disorders.