Dexamethasone
[CAS# 50-02-2]

Identification

• Classification: API >> Hormone and endocrine-regulating drugs >> Adrenal corticosteroids
• Name: Dexamethasone
• Synonyms: 9alpha-Fluoro-11beta,17alpha,21-trihydroxy-16alpha-methylpregn-1,4-diene-3,20-dione
• Molecular Formula: C₂₂H₂₉FO₅
• Molecular Weight: 392.46
• CAS Registry Number: 50-02-2
• EC Number: 200-003-9

Properties

• Melting point: 255-264 ºC
• alpha: 75 º (c=1, dioxane)
• Water solubility: 10 mg/100 mL (25 ºC)

Safety Data

• Hazard Symbols: Xn
• Risk Codes: R40
• Safety Description: S45

Hazard Classification

Hazard	Class	Category Code	Hazard Statement
Reproductive toxicity	Repr.	1B	H360
Specific target organ toxicity - repeated exposure	STOT RE	2	H373
Chronic hazardous to the aquatic environment	Aquatic Chronic	1	H410
Skin sensitization	Skin Sens.	1	H317
Eye irritation	Eye Irrit.	2	H319
Specific target organ toxicity - single exposure	STOT SE	3	H335
Respiratory sensitization	Resp. Sens.	1	H334
Skin irritation	Skin Irrit.	2	H315
Reproductive toxicity	Repr.	1B	H360D
Reproductive toxicity	Repr.	2	H361
Specific target organ toxicity - repeated exposure	STOT RE	1	H372
Reproductive toxicity	Repr.	1B	H360FD
Carcinogenicity	Carc.	2	H351
Specific target organ toxicity - single exposure	STOT SE	3	H336
Reproductive toxicity	Lact.	-	H362
Acute toxicity	Acute Tox.	4	H302