3-Ethyl 5-Methyl 2-[(2-Aminoethoxy)Methyl]-4-(2-Chlorophenyl)-6-Methyl-1,4-Dihydro-3,5-Pyridinedicarboxylate
[CAS# 103129-81-3]

Identification

• Classification: API >> Circulatory system medication >> Prevention and treatment of angina pectoris
• Name: 3-Ethyl 5-Methyl 2-[(2-Aminoethoxy)Methyl]-4-(2-Chlorophenyl)-6-Methyl-1,4-Dihydro-3,5-Pyridinedicarboxylate
• Synonyms: "3-ethyl 5-methyl ester 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylic acid"; (R)-Amlodipine; (S)-Amlodipine; (4S)-2-[(2-Aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylic acid 3-ethyl 5-methyl ester
• Molecular Formula: C₂₀H₂₅ClN₂O₅
• Molecular Weight: 408.88
• CAS Registry Number: 103129-81-3
• SMILES: CCOC(=O)C1=C(NC(=C(C1C2=CC=CC=C2Cl)C(=O)OC)C)COCCN
• InChI: 1S/C20H25ClN2O5/c1-4-28-20(25)18-15(11-27-10-9-22)23-12(2)16(19(24)26-3)17(18)13-7-5-6-8-14(13)21/h5-8,17,23H,4,9-11,22H2,1-3H3
• InChIKey: HTIQEAQVCYTUBX-UHFFFAOYSA-N

Properties

• Density: 1.2±0.1g/cm³ (Cal.)
• Boiling point: 527.2±50.0°C at 760 mmHg (Cal.)
• Flash point: 272.6±30.1°C (Cal.)
• Refractive index: 1.546 (Cal.)

References

• (1): Sina Haas, Heinz-Georg Jahnke, Marco Glass, Ronny Azendorf, Sabine Schmidt and Andrea A. Robitzki. Real-time monitoring of relaxation and contractility of smooth muscle cells on a novel biohybrid chip, Lab Chip, 2010, 10, 2965.