1-Methoxy-2-propyl acetate
[CAS# 108-65-6]

Identification

• Classification: Chemical reagent >> Organic reagent >> Ester >> Acid ester compound
• Name: 1-Methoxy-2-propyl acetate
• Synonyms: 1,2-Propanediol monomethyl ether acetate; Propylene glycol methyl ether acetate; MPA
• Molecular Formula: C₆H₁₂O₃
• Molecular Weight: 132.16
• CAS Registry Number: 108-65-6
• EC Number: 203-603-9
• SMILES: CC(COC)OC(=O)C

Properties

• Density: 0.96
• Melting point: -87 °C
• Boiling point: 146 °C
• Refractive index: 1.401-1.403
• Flash point: 42 °C
• Water solubility: 19.8 g/L (25 °C)

Safety Data

• Hazard Symbols: GHS02;GHS07 Warning
• Risk Statements: H226-H336
• Safety Statements: P210-P233-P240-P241-P242-P243-P261-P271-P280-P303+P361+P353-P304+P340-P319-P370+P378-P403+P233-P403+P235-P405-P501

Hazard Classification

Hazard	Class	Category Code	Hazard Statement
Flammable liquids	Flam. Liq.	3	H226
Specific target organ toxicity - single exposure	STOT SE	3	H336
Eye irritation	Eye Irrit.	2	H319
Serious eye damage	Eye Dam.	1	H318
Reproductive toxicity	Repr.	1B	H360
Skin irritation	Skin Irrit.	2	H315
Specific target organ toxicity - single exposure	STOT SE	3	H335
Flammable liquids	Flam. Liq.	2	H225
Skin sensitization	Skin Sens.	1	H317
Specific target organ toxicity - repeated exposure	STOT RE	2	H373
Acute toxicity	Acute Tox.	4	H302

• Transport Information: UN 3271

Discovery and Applications

1-Methoxy-2-propyl acetate, also known as propylene glycol monomethyl ether acetate (PGMEA), is a widely used solvent in various industrial applications. It belongs to the family of glycol ethers and was developed as an efficient solvent due to its unique chemical properties, which include moderate volatility, high solvency power, and a relatively low level of toxicity compared to other solvents. PGMEA gained prominence in the mid-20th century as industries sought safer and more effective alternatives to traditional solvents, particularly in coatings and cleaning agents.

One of the primary applications of 1-Methoxy-2-propyl acetate is in the production of paints, inks, and coatings. Its ability to dissolve a wide range of resins makes it an excellent solvent for use in automotive, architectural, and industrial coatings. In particular, it is valued for its role in high-performance coatings where quick drying and smooth application are essential. Additionally, its low toxicity and environmental profile compared to more hazardous solvents make it a preferred choice in formulations designed to meet stricter regulatory standards for emissions and worker safety.

PGMEA is also used extensively in the electronics industry. In semiconductor manufacturing, it serves as a solvent for photoresist materials used in photolithography, a critical process in the production of microchips and other electronic components. Its high purity and ability to evaporate without leaving residues make it ideal for this application, where precision and cleanliness are paramount.

Another important use of 1-Methoxy-2-propyl acetate is as a cleaning agent in both industrial and household contexts. Its strong solvency capabilities allow it to remove oils, greases, and other contaminants from surfaces without causing damage. It is found in many formulations of degreasers, paint thinners, and general-purpose cleaners.

Moreover, PGMEA is utilized in the formulation of adhesives, lacquers, and varnishes. Its chemical properties ensure that these products maintain the necessary viscosity and drying characteristics, providing a smooth finish and long-lasting durability.

References

2024. Preparation and characterization of Ag conductive adhesive with low resistivity. Journal of Materials Science: Materials in Electronics.
DOI: 10.1007/s10854-024-13621-1

2024. Development of near-infrared reflective inorganic pigment dispersions in the continuous phase of solvent-binder medium. Journal of Coatings Technology and Research.
DOI: 10.1007/s11998-024-00946-z

2024. Exploration of organic matrixes in conductive silver paste: a comprehensive review. Journal of Materials Science: Materials in Electronics.
DOI: 10.1007/s10854-024-13047-9