7-Methoxy-2,2-dimethylchroman-6-yl palmitate
[CAS# 1105025-85-1]

Identification

• Classification: Flavors and spices >> Synthetic spice >> Carboxylic acid and ester perfume >> Aromatic carboxylic acid ester
• Name: 7-Methoxy-2,2-dimethylchroman-6-yl palmitate
• Molecular Formula: C₂₈H₄₆O₄
• Molecular Weight: 446.66
• CAS Registry Number: 1105025-85-1
• SMILES: CCCCCCCCCCCCCCCC(=O)OC1=C(C=C2C(=C1)CCC(O2)(C)C)OC

Properties

• Density: 1.0±0.1 g/cm³, Calc.^*
• Index of Refraction: 1.489, Calc.^*
• Boiling Point: 518.8±50.0 °C (760 mmHg), Calc.^*
• Flash Point: 216.4±30.2 °C, Calc.^*

^* Calculated using Advanced Chemistry Development (ACD/Labs) Software.

Discovery and Applications

7-Methoxy-2,2-dimethylchroman-6-yl palmitate, also known as vitamin E TPGS (tocopherol), is a derivative of vitamin E. The discovery of 7-methoxy-2,2-dimethylchroman-6-yl palmitate stems from research into the biological activities of vitamin E and its derivatives. Vitamin E is a class of lipid-soluble antioxidants that was first discovered in 1922 by researchers Herbert Evans and Katherine Bishop while studying the nutritional requirements of rats. Further studies have shown that it plays an important role in protecting cells from oxidative damage caused by free radicals. The synthesis of 7-methoxy-2,2-dimethylchroman-6-yl palmitate uses palmitated vitamin E, resulting in a compound that is more soluble in lipids and more bioavailable. 7-Methoxy-2,2-dimethylchroman-6-yl palmitate is widely used as a solubilizer and emulsifier in drug delivery systems. Its amphiphilic nature allows it to solubilize poorly water-soluble drugs, thereby improving bioavailability and therapeutic efficacy. Additionally, 7-methoxy-2,2-dimethylchroman-6-yl palmitate has been shown to improve the stability and pharmacokinetics of drugs, making it an essential excipient in formulations such as oral tablets, capsules, and injections.7-Methoxy-2,2-dimethylchroman-6-yl palmitate is used in cosmetic manufacturing for its skin conditioning properties and antioxidant benefits. It helps moisturize the skin while protecting it from oxidative stress and environmental damage. Additionally, 7-methoxy-2,2-dimethylchroman-6-yl palmitate has been shown to enhance the stability and efficacy of other active ingredients in skin care formulations, making it a popular choice for anti-aging creams, lotions, and serums.In the food and beverage industry, 7-methoxy-2,2-dimethylchroman-6-yl palmitate is used as a dietary supplement to enhance the absorption of fat-soluble vitamins and nutrients. Its ability to improve the solubility and bioavailability of lipophilic compounds makes it an ideal additive in fortified foods, beverages, and nutritional supplements. Research into the therapeutic potential of 7-methoxy-2,2-dimethylchroman-6-yl palmitate is ongoing, exploring its role in a variety of health conditions, including cancer, cardiovascular disease, and neurodegenerative diseases. Preliminary studies suggest that 7-methoxy-2,2-dimethylchroman-6-yl palmitate may have protective effects against oxidative stress, inflammation, and cellular damage, making it a promising candidate for the prevention and treatment of chronic diseases.

References

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