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2-Butoxyethanol
[CAS# 111-76-2]

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Identification
ClassificationOrganic raw materials >> Ether compounds and their derivatives >> Ether, ether alcohol
Name2-Butoxyethanol
Synonyms2-n-Butoxyethanol; Butyl cellosolve; Ethylene glycol monobutyl ether
Molecular StructureCAS # 111-76-2, 2-Butoxyethanol
Molecular FormulaC6H14O2
Molecular Weight118.17
CAS Registry Number111-76-2
EC Number203-905-0
SMILESCCCCOCCO
Properties
Density0.9±0.1 g/cm3, Calc.*, 0.902 g/mL (Expl.)
Melting point-75 °C (Expl.)
Index of Refraction1.418, Calc.*, 1.419 (Expl.)
Boiling Point167.7±8.0 °C (760 mmHg), Calc.*, 169-172.5 °C (Expl.)
Flash Point60.0±0.0 °C, Calc.*, 67 °C (Expl.)
Water solubilitymiscible (Expl.)
*Calculated using Advanced Chemistry Development (ACD/Labs) Software.
Safety Data
Hazard Symbolssymbol symbol   GHS06;GHS07 Warning  Details
Risk StatementsH331-H302-H315-H319  Details
Safety StatementsP264-P264+P265-P270-P280-P301+P317-P302+P352-P305+P351+P338-P305+P354+P338-P317-P321-P330-P337+P317-P362+P364-P501  Details
Hazard Classification
up    Details
HazardClassCategory CodeHazard Statement
Skin irritationSkin Irrit.2H315
Acute toxicityAcute Tox.4H302
Eye irritationEye Irrit.2H319
Acute toxicityAcute Tox.4H332
Acute toxicityAcute Tox.4H312
Acute toxicityAcute Tox.3H331
Acute toxicityAcute Tox.3H311
Specific target organ toxicity - repeated exposureSTOT RE2H373
Acute toxicityAcute Tox.2H330
Skin sensitizationSkin Sens.1H317
Acute toxicityAcute Tox.2H310
Acute toxicityAcute Tox.1H330
Reproductive toxicityRepr.2H361
Germ cell mutagenicityMuta.2H341
Serious eye damageEye Dam.1H318
Acute toxicityAcute Tox.3H301
CarcinogenicityCarc.2H351
Specific target organ toxicity - single exposureSTOT SE1H370
Flammable liquidsFlam. Liq.2H225
Chronic hazardous to the aquatic environmentAquatic Chronic2H411
Transport InformationUN 2369
SDSAvailable
up Discovery and Applications
2-Butoxyethanol, also known as ethylene glycol monobutyl ether (EGMBE), is an organic solvent with the chemical formula C6H14O2. It is a colorless liquid with a mild odor, and it is commonly used as a solvent in industrial cleaning, coatings, and manufacturing processes. The compound has a broad range of applications due to its excellent solvent properties, particularly in dissolving oils, greases, and resins. Its discovery and extensive use in various industries have made it an essential chemical for many commercial and industrial applications.

2-Butoxyethanol was first synthesized in the 1930s as part of early research into the properties of glycol ethers. The compound is produced by the reaction of butyl alcohol with ethylene oxide, a process that yields a range of glycol ether compounds. As a member of the glycol ether family, 2-butoxyethanol combines the solvent properties of both alcohols and ethers, making it an effective substance for a variety of cleaning and manufacturing tasks. Over time, its role in industrial processes has become more prominent, especially in sectors where high-performance solvents are required.

One of the primary applications of 2-butoxyethanol is in the formulation of cleaning products. Its ability to dissolve oils, greases, and other hydrophobic materials makes it an excellent solvent for degreasing and cleaning operations. It is commonly found in industrial cleaning products such as degreasers, floor cleaners, and graffiti removers. Additionally, it is used in household products like glass cleaners and surface disinfectants. Due to its high solvency power, 2-butoxyethanol can effectively remove stubborn contaminants from surfaces, machinery, and equipment.

In addition to its use as a cleaning agent, 2-butoxyethanol is also widely used as a solvent in the coatings and paint industry. It is included in many formulations for paints, varnishes, and lacquers due to its ability to dissolve a wide range of resins, making it easier to apply and spread the coatings evenly. The compound also helps improve the flow and leveling properties of paints, reducing the occurrence of brush marks and streaks. Furthermore, its low volatility allows for smoother application in environments with varying humidity and temperature levels.

Another key application of 2-butoxyethanol is in the manufacture of inks, adhesives, and hydraulic fluids. It is used in ink formulations for printing because it ensures that the ink dries properly while maintaining good adhesion to surfaces. In adhesives, it functions as a solvent to improve the application and bonding of materials. 2-Butoxyethanol is also used in hydraulic fluid formulations, where it serves as a stabilizing agent and ensures smooth operation in hydraulic systems.

Despite its versatility, 2-butoxyethanol is not without its safety concerns. The compound can pose health risks if not handled properly. Prolonged exposure to 2-butoxyethanol can lead to irritation of the skin, eyes, and respiratory system. Inhalation of the vapors can cause headaches, dizziness, and nausea. The compound is also classified as a possible reproductive toxin, and it may have other long-term health effects if exposure is prolonged or occurs at high concentrations. Therefore, it is important to follow safety guidelines and wear protective equipment when working with this substance.

Due to growing environmental concerns, there have been efforts to replace 2-butoxyethanol in certain applications with safer or more sustainable alternatives. In response to health and environmental risks, manufacturers have developed low-odor and low-toxicity formulations, though 2-butoxyethanol remains a widely used solvent in many industries.

In conclusion, 2-butoxyethanol is an important chemical compound used primarily as a solvent in cleaning products, coatings, inks, and adhesives. Its discovery and subsequent applications have made it indispensable in a variety of industrial and commercial sectors. While its properties make it highly effective in these applications, its potential health and environmental risks necessitate careful handling and ongoing research into safer alternatives.

References

2016. Adsorption of hydraulic fracturing fluid components 2-butoxyethanol and furfural onto granular activated carbon and shale rock. Chemosphere.
DOI: 10.1016/j.chemosphere.2016.09.010

2003. Ocular expression of vascular cell adhesion molecule (VCAM-1) in 2-butoxyethanol-induced hemolysis and thrombosis in female rats. Experimental and Toxicologic Pathology.
DOI: 10.1078/0940-2993-00321

1994. Inhalation toxicokinetics of butoxyethanol and its metabolite butoxyacetic acid in the male Sprague-Dawley rat. Archives of Toxicology.
DOI: 10.1007/s002040050119
Market Analysis Reports
List of Reports Available for 2-Butoxyethanol
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