2-Amino-N-(2,2,2-trifluoroethyl)acetamide hydrochloride
[CAS# 1171331-39-7]

Identification

• Classification: Organic raw materials >> Amino compound >> Amide compound
• Name: 2-Amino-N-(2,2,2-trifluoroethyl)acetamide hydrochloride
• Molecular Formula: C₄H₈ClF₃N₂O
• Molecular Weight: 192.57
• CAS Registry Number: 1171331-39-7
• EC Number: 806-518-0
• SMILES: C(C(=O)NCC(F)(F)F)N.Cl

Safety Data

• Hazard Symbols: GHS07 Warning
• Risk Statements: H302-H315-H319-H335
• Safety Statements: P261-P305+P351+P338

Hazard Classification

Hazard	Class	Category Code	Hazard Statement
Specific target organ toxicity - single exposure	STOT SE	3	H335
Skin irritation	Skin Irrit.	2	H315
Eye irritation	Eye Irrit.	2A	H319
Eye irritation	Eye Irrit.	2	H319

Discovery and Applications

2-Amino-N-(2,2,2-trifluoroethyl)acetamide hydrochloride is a chemical compound notable for its distinctive structure and wide range of applications in both research and industry. This compound, commonly referred to by its chemical name, is a derivative of acetamide with a trifluoroethyl group and an amino substituent.

The discovery of 2-amino-N-(2,2,2-trifluoroethyl)acetamide hydrochloride stemmed from efforts to explore the chemical properties and applications of trifluoroethyl derivatives. The introduction of the trifluoroethyl group into the acetamide structure was a strategic choice aimed at enhancing the compound's reactivity and stability. The trifluoroethyl group, known for its electron-withdrawing properties, imparts unique characteristics to the molecule, making it valuable in various chemical contexts.

The synthesis of 2-amino-N-(2,2,2-trifluoroethyl)acetamide hydrochloride typically involves the reaction of 2-aminoacetamide with 2,2,2-trifluoroethyl chloride under controlled conditions. The resulting hydrochloride salt form is commonly used to facilitate the handling and solubility of the compound in aqueous solutions. This preparation method ensures the production of a high-purity product suitable for diverse applications.

One of the primary applications of 2-amino-N-(2,2,2-trifluoroethyl)acetamide hydrochloride is in medicinal chemistry. The trifluoroethyl group enhances the molecule's metabolic stability and influences its interaction with biological targets. As a result, this compound has been explored for its potential use in drug development. The presence of the amino group allows for further chemical modifications, leading to the synthesis of novel compounds with improved pharmacological properties. Researchers have investigated its potential as a building block for pharmaceuticals aimed at treating various diseases.

In addition to its role in drug development, 2-amino-N-(2,2,2-trifluoroethyl)acetamide hydrochloride finds applications in the field of agrochemicals. The trifluoroethyl group contributes to the compound's ability to interact with biological systems, making it a candidate for designing new agrochemical agents. Its properties can be leveraged to develop herbicides or insecticides with enhanced efficacy and selectivity.

Another notable application of this compound is in the field of materials science. The trifluoroethyl group imparts unique physical and chemical properties to the molecule, making it useful for creating advanced materials. By incorporating 2-amino-N-(2,2,2-trifluoroethyl)acetamide hydrochloride into polymer matrices or other material systems, researchers can design materials with specific characteristics, such as increased thermal stability or chemical resistance.

Overall, 2-amino-N-(2,2,2-trifluoroethyl)acetamide hydrochloride is a versatile chemical substance with significant implications for medicinal chemistry, agrochemical development, and materials science. Its unique combination of functional groups makes it a valuable tool for researchers and industry professionals seeking to explore new chemical transformations and applications.

References

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