Pyrroloquinolinequinone disodium salt
[CAS# 122628-50-6]

Identification

• Classification: Pharmaceutical intermediate >> Heterocyclic compound intermediate >> Quinoline compound
• Name: Pyrroloquinolinequinone disodium salt
• Synonyms: disodium;2-carboxy-4,5-dioxo-1H-pyrrolo[2,3-f]quinoline-7,9-dicarboxylate
• Molecular Formula: C₁₄H₄N₂O₈.₂Na
• Molecular Weight: 374.17
• CAS Registry Number: 122628-50-6
• EC Number: 961-572-3
• SMILES: C1=C(C2=C(C(=O)C(=O)C3=C2NC(=C3)C(=O)O)N=C1C(=O)[O-])C(=O)[O-].[Na+].[Na+]

Safety Data

• Hazard Symbols: GHS07 Warning
• Risk Statements: H302
• Safety Statements: P264-P270-P301+P317-P330-P501

Hazard Classification

Hazard	Class	Category Code	Hazard Statement
Acute toxicity	Acute Tox.	4	H302

Discovery and Applications

Pyrroloquinolinequinone disodium salt (PQQ) is a redox-active compound derived from pyrroloquinoline quinone, a molecule first identified in the 1970s as a cofactor for bacterial enzymes. Researchers discovered PQQ while studying bacterial methanol dehydrogenases, which use the compound as an essential cofactor for catalyzing redox reactions. This discovery marked PQQ as a novel biological redox agent, initiating further investigation into its structure, synthesis, and biological activity. Over time, PQQ’s relevance has expanded from microbial systems to potential applications in human health, spurring interest in its use as a supplement due to possible antioxidant and neuroprotective properties.

PQQ disodium salt is highly valued for its role in supporting mitochondrial function and energy production in human cells. Studies have shown that PQQ can enhance mitochondrial biogenesis, the process by which new mitochondria are formed. Mitochondria play a critical role in cellular metabolism and energy production, and PQQ’s ability to stimulate mitochondrial growth has made it an attractive compound in the field of anti-aging and neuroprotection. Due to its potential in supporting mitochondrial health, PQQ disodium salt is included in dietary supplements aimed at enhancing cognitive function, increasing energy levels, and reducing oxidative stress.

Another prominent application of PQQ disodium salt is in the field of antioxidation. PQQ is recognized as a powerful antioxidant that can neutralize free radicals and prevent cellular damage caused by oxidative stress. This property is especially important in protecting neurons, and research indicates that PQQ could have a neuroprotective effect, potentially reducing the risk of neurodegenerative diseases. Current studies are exploring PQQ’s impact on cognitive health and its ability to mitigate conditions like Alzheimer’s disease and Parkinson’s disease. Its antioxidant properties are also being examined for cardiovascular health, as reducing oxidative stress is essential for maintaining healthy blood vessels and heart function.

Furthermore, PQQ disodium salt has potential applications in the agricultural and food industries. Due to its stability and redox activity, PQQ can be used as a natural preservative to enhance food shelf life by inhibiting oxidative spoilage. Additionally, in plant biology, PQQ has shown promise in promoting seed germination and plant growth, suggesting potential use as a biostimulant in agriculture. This versatility demonstrates PQQ’s potential beyond human health, making it a valuable compound in both scientific research and industrial applications.

References

2018. The Chemical and Products Database, a resource for exposure-relevant data on chemicals in consumer products. Scientific Data, 5, 180125.
DOI: 10.1038/sdata.2018.125

1991. United States Patent Document #5061711. ChemIDplus