2-(Bromomethyl)-5-chloropyrimidine
[CAS 1227577-50-5]

Identification

• Classification: Pharmaceutical intermediate >> Heterocyclic compound intermediate >> Pyrimidine compound >> Chloropyrimidine
• Name: 2-(Bromomethyl)-5-chloropyrimidine
• Molecular Formula: C₅H₄BrClN₂
• Molecular Weight: 207.46
• CAS Registry Number: 1227577-50-5
• SMILES: C1=C(C=NC(=N1)CBr)Cl

Properties

• Density: 1.8±0.1 g/cm³ Calc.^*
• Boiling point: 228.3±20.0 °C 760 mmHg (Calc.)^*
• Flash point: 91.8±21.8 °C (Calc.)^*
• Index of refraction: 1.597 (Calc.)^*

^* Calculated using Advanced Chemistry Development (ACD/Labs) Software.

Safety Data

• Hazard Symbols: GHS05;GHS07 Danger
• Risk Statements: H302-H335-H314
• Safety Statements: P260-P264-P270-P271-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P310-P363-P403+P233-P405-P501
• Transport Information: UN 3261

chemBlink Chemical Story

2-(Bromomethyl)-5-chloropyrimidine (CAS 1227577-50-5) is a halogenated pyrimidine building block whose value lies in having two chemically different reactive sites in one compact heteroaromatic molecule. The bromomethyl group is a useful electrophilic handle for substitution by nitrogen, oxygen, sulfur, and other nucleophiles, while the chlorine attached to the electron-poor pyrimidine ring can participate in later substitution or coupling chemistry. This orthogonality lets medicinal and process chemists elaborate the molecule stepwise rather than modifying every position at once. Public exact-CAS literature is limited and does not support assigning this material a single approved therapeutic role. It is best described as a research and synthesis intermediate used to construct more complex pyrimidine-containing molecules.

Chemical identity is more than a name. Closely related salts, isomers, hydrates, metabolites, intermediates, and final products can have different registry numbers and different physical or biological behavior. For a chemical database, keeping those forms separate prevents a property measured for one substance from being silently assigned to another.

Synthesis also depends on chemoselectivity. A useful intermediate contains functional groups that can be transformed in a predictable order, allowing chemists to build complexity while protecting parts of the molecule that must remain unchanged. This is why apparently modest building blocks can be important in medicinal, materials, or process chemistry even when they never appear in a finished product.

Analytical control is the other half of synthesis. Identity, purity, water or salt content, stereochemistry, and process-related impurities may all matter to reproducibility. Reference standards and well-characterized intermediates therefore have value beyond their immediate reaction step: they allow laboratories to confirm that a route is producing the intended chemical entity.

A responsible Chemical Story separates documented application from structural possibility. Familiar motifs can suggest hypotheses, but structural resemblance alone does not prove pharmacological activity, industrial adoption, or regulatory status. Where exact-CAS literature is sparse, the scientifically useful approach is to describe verified chemistry and stop before speculation becomes a claimed fact.

Chemical identity is more than a name. Closely related salts, isomers, hydrates, metabolites, intermediates, and final products can have different registry numbers and different physical or biological behavior. For a chemical database, keeping those forms separate prevents a property measured for one substance from being silently assigned to another.

Synthesis also depends on chemoselectivity. A useful intermediate contains functional groups that can be transformed in a predictable order, allowing chemists to build complexity while protecting parts of the molecule that must remain unchanged. This is why apparently modest building blocks can be important in medicinal, materials, or process chemistry even when they never appear in a finished product.

Analytical control is the other half of synthesis. Identity, purity, water or salt content, stereochemistry, and process-related impurities may all matter to reproducibility. Reference standards and well-characterized intermediates therefore have value beyond their immediate reaction step: they allow laboratories to confirm that a route is producing the intended chemical entity.

A responsible Chemical Story separates documented application from structural possibility. Familiar motifs can suggest hypotheses, but structural resemblance alone does not prove pharmacological activity, industrial adoption, or regulatory status. Where exact-CAS literature is sparse, the scientifically useful approach is to describe verified chemistry and stop before speculation becomes a claimed fact.

Chemical identity is more than a name. Closely related salts, isomers, hydrates, metabolites, intermediates, and final products can have different registry numbers and different physical or biological behavior. For a chemical database, keeping those forms separate prevents a property measured for one substance from being silently assigned to another.

References:
1. Specialist chemical catalogs. CAS 1227577-50-5 identity and structure.
2. General literature on halopyrimidines as heteroaromatic synthetic building blocks.

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