2-Amino-2-methyl-1-propanol
[CAS# 124-68-5]

Identification

• Classification: Chemical reagent >> Organic reagent >> Fatty alcohol
• Name: 2-Amino-2-methyl-1-propanol
• Synonyms: 2-Amino-2-methyl-propan-1-ol; Karl Fischer; Aqualine Electrolyte AD-G
• Molecular Formula: C₄H₁₁NO
• Molecular Weight: 89.14
• Protein Sequence: X
• CAS Registry Number: 124-68-5
• EC Number: 204-709-8
• SMILES: CC(C)(CO)N

Properties

• Density: 0.934
• Melting point: 24-28 °C
• Boiling point: 165 °C
• Refractive index: 1.4455
• Water solubility: miscible

Safety Data

• Hazard Symbols: GHS07 Warning
• Risk Statements: H315-H319-H412
• Safety Statements: P264-P264+P265-P273-P280-P302+P352-P305+P351+P338-P321-P332+P317-P337+P317-P362+P364-P501

Hazard Classification

Hazard	Class	Category Code	Hazard Statement
Skin irritation	Skin Irrit.	2	H315
Eye irritation	Eye Irrit.	2	H319
Chronic hazardous to the aquatic environment	Aquatic Chronic	3	H412
Serious eye damage	Eye Dam.	1	H318
Chronic hazardous to the aquatic environment	Aquatic Chronic	1	H410
Eye irritation	Eye Irrit.	2	H320
Acute hazardous to the aquatic environment	Aquatic Acute	3	H402

Discovery and Applications

2-Amino-2-methyl-1-propanol, also known as AMP, is a popular organic compound due to its versatile properties and wide applications in various industries. 2-Amino-2-methyl-1-propanol is a clear, colorless liquid at room temperature with a mild ammonia odor. It is soluble in water and miscible with many organic solvents, facilitating its use in a variety of formulations and reactions. The presence of both amino and hydroxyl groups in its structure enables AMP to serve as a versatile building block in organic synthesis and chemical transformations.

The discovery of 2-amino-2-methyl-1-propanol can be traced back to the advancement of organic synthesis technology. It is an amino alcohol synthesized by the reaction of ammonia with 2-methyl-1-propanol. The compound is characterized by its primary amino group (-NH2) attached to a secondary carbon atom and combined with a methyl group (-CH3), giving it unique chemical and functional properties.

AMP is widely used in the production of surfactants and emulsifiers. Its amphiphilic nature enables it to reduce surface tension and stabilize emulsions in personal care products, detergents, and industrial cleaners.

AMP is used as a corrosion inhibitor in industrial applications such as metalworking fluids, cooling systems, and oilfield chemicals due to its ability to form a protective layer on metal surfaces.

AMP is used as a pH adjuster and buffer in various chemical processes and formulations. Its buffering capacity stabilizes pH and is therefore valuable in pharmaceuticals, cosmetics, and agricultural products.

In polymer chemistry, AMP is used as a catalyst and pH adjuster in the synthesis of polyurethanes and other polymers. Its role in controlling reaction kinetics and polymer structure improves the efficiency and performance of polymerization processes.

In addition to its industrial uses, 2-amino-2-methyl-1-propanol has applications in the biomedical and pharmaceutical fields. AMP is used as a precursor for the synthesis of pharmaceutical compounds and active ingredients as it is a versatile building block in organic synthesis. It is used in the formulation of drug delivery systems, where its solubility and stability improve the efficacy and bioavailability of active pharmaceutical ingredients (APIs). AMP is an integral part of biochemical research and biotechnological applications as a component of cell culture media and protein purification processes.

References

1953. A study of diuretic action of Pamabrom (2-amino-2-methyl-propanol-1-8-bromotheophylline) in cardiac failure. American Heart Journal.
DOI: 10.1016/0002-8703(53)90208-7

2023. Developmental and reproductive toxicity hazard characterization of 2‐amino‐2‐methyl‐1‐propanol (AMP). Journal of Applied Toxicology.
DOI: 10.1002/jat.4539

2024. Comparative Analysis of CO2 Adsorption Capacity for Amine-Modified Activated Carbon Prepared from Jujube Seed. Pollution Control for Clean Environment — Volume 2.
DOI: 10.1007/978-981-97-7846-1_11