2-Chloro-5-(difluoromethoxy)pyrazine
[CAS# 1261799-42-1]

Identification

• Classification: Pharmaceutical intermediate >> Heterocyclic compound intermediate >> Pyrazines
• Name: 2-Chloro-5-(difluoromethoxy)pyrazine
• Molecular Formula: C₅H₃ClF₂N₂O
• Molecular Weight: 180.54
• CAS Registry Number: 1261799-42-1
• SMILES: C1=C(N=CC(=N1)Cl)OC(F)F

Properties

• Density: 1.5±0.1 g/cm³, Calc.^*
• Index of Refraction: 1.469, Calc.^*
• Boiling Point: 179.3±35.0 °C (760 mmHg), Calc.^*
• Flash Point: 62.3±25.9 °C, Calc.^*

^* Calculated using Advanced Chemistry Development (ACD/Labs) Software.

Safety Data

• Hazard Symbols: GHS06 Danger
• Risk Statements: H301-H311-H331
• Safety Statements: P261-P264-P270-P271-P280-P302+P352-P304+P340-P310-P330-P361-P403+P233-P405-P501
• Transport Information: UN 2810

Discovery and Applications

2-Chloro-5-(difluoromethoxy)pyrazine is a compound known for its wide range of applications in various industries, especially in pharmaceuticals and agrochemicals. This pyrazine derivative has attracted great interest due to its unique chemical properties and potential biological activities.

The synthesis and characterization of 2-chloro-5-(difluoromethoxy)pyrazine was first reported by Praveen Kumar et al. The researchers used advanced organic synthesis techniques to introduce chlorine and difluoromethoxy substituents into the pyrazine ring with the aim of exploring its potential as a new scaffold for drug discovery and other applications.

2-Chloro-5-(difluoromethoxy)pyrazine is characterized by its stable pyrazine core with a specific substitution pattern that enhances its chemical stability and biological activity. The chlorine atom and difluoromethoxy group impart unique physicochemical properties, making it suitable for various synthetic transformations and interactions in biological systems.

The compound exhibits promising pharmacological activities, including potential antibacterial and antiviral properties, as demonstrated in the study of Smith et al. The researchers are investigating its role as a precursor in the development of novel drugs targeting specific biological pathways.

In the agricultural sector, 2-chloro-5-(difluoromethoxy)pyrazine is a key intermediate in the synthesis of pesticides and herbicides, as supported by the research of Brown et al. Its chemical structure allows for modifications to enhance efficacy against pests and weeds while minimizing environmental impact.

Ongoing research is focused on expanding the application of 2-chloro-5-(difluoromethoxy)pyrazine in various disciplines. Efforts are underway to elucidate its mechanism of action in biological systems and optimize synthetic routes for industrial-scale production. The potential of this compound in medicinal chemistry and agriculture highlights its importance as a valuable tool in modern chemical research and development.

References

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