N-(Pyrimidin-5-ylmethyl)pyridin-2-amine
[CAS# 1383916-51-5]

Identification

• Classification: Pharmaceutical intermediate >> Heterocyclic compound intermediate >> Pyrimidine compound
• Name: N-(Pyrimidin-5-ylmethyl)pyridin-2-amine
• Molecular Formula: C₁₀H₁₀N₄
• Molecular Weight: 186.21
• CAS Registry Number: 1383916-51-5
• SMILES: C1=CC=NC(=C1)NCC2=CN=CN=C2

Properties

• Density: 1.2±0.1 g/cm³, Calc.^*
• Index of Refraction: 1.653, Calc.^*
• Boiling Point: 360.1±22.0 °C (760 mmHg), Calc.^*
• Flash Point: 171.6±22.3 °C, Calc.^*

^* Calculated using Advanced Chemistry Development (ACD/Labs) Software.

Safety Data

• Hazard Symbols: GHS07 Warning
• Risk Statements: H302-H315-H319-H335
• Safety Statements: P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P330-P362-P403+P233-P501

Discovery and Applications

The synthesis of N-(pyrimidin-5-ylmethyl)pyridin-2-amine involves the condensation of pyridin-2-amine with a pyrimidine derivative bearing a methyl group at the fifth position. The synthesis produces a crystalline solid with a specific molecular arrangement characterized by the substitution of the pyridine ring at one end with a pyrimidine moiety and at the other end with an amine group. The discovery of this compound has opened up new avenues in medicinal chemistry and chemical synthesis, providing potential applications in drug discovery and materials science.

From a chemical point of view, N-(pyrimidin-5-ylmethyl)pyridin-2-amine is characterized by its fused heterocyclic structure, which includes a pyridine ring fused to a pyrimidine ring. This molecular structure confers it with specific physical and chemical properties, such as solubility, stability, and reactivity, which are essential for its various applications in organic synthesis and drug development.

The compound is a valuable intermediate for the synthesis of pharmaceutical agents targeting various biological pathways. Its structural versatility allows modifications to enhance biological activity, bioavailability, and therapeutic effects, thereby aiding drug development efforts.

N-(pyrimidin-5-ylmethyl)pyridin-2-amine can be used as a building block in organic synthesis for the preparation of novel chemical entities and functional materials. Its incorporation enhances the diversity and functionality of molecules, supporting advances in chemical manufacturing and materials science.

The unique chemical properties of this compound make it useful for biotechnological applications, including molecular probes, fluorescent dyes, and biochemical assays. Its selective interaction with biological targets facilitates the study of biochemical pathways and diagnostic techniques.

The ongoing research program focuses on exploring the potential of N-(pyrimidin-5-ylmethyl)pyridin-2-amine in the following aspects: investigating its pharmacological properties and therapeutic applications through structure-activity relationship studies and preclinical evaluations, aiming to identify new drug candidates for various therapeutic indications; exploring its role in materials science applications, including polymer chemistry, nanotechnology, and surface modification, using its heterocyclic structure for functional materials design and development; evaluating its environmental trajectory and impacts to ensure sustainable synthetic routes and minimize the ecological footprint of industrial processes.

Studies on the safety and regulatory compliance of N-(5-pyrimidinylmethyl)pyridin-2-amine ensure its safe handling and use in industrial applications. The regulatory framework involves environmental impact assessments, occupational health guidelines, and product stewardship to mitigate potential risks associated with its manufacture and use.

References

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