5-Oxa-2-octyne-1,7-diol
[CAS# 1606-79-7]

Identification

• Classification: Pharmaceutical intermediate >> Heterocyclic compound intermediate >> Pyrimidine compound >> Alcohol
• Name: 5-Oxa-2-octyne-1,7-diol
• Synonyms: 4-(2-Hydroxypropoxy)but-2-yn-1-ol; Butynediol propoxylate; BMP
• Molecular Formula: C₇H₁₂O₃
• Molecular Weight: 144.17
• CAS Registry Number: 1606-79-7
• EC Number: 216-522-9
• SMILES: CC(COCC#CCO)O

Safety Data

• Hazard Symbols: GHS07 Warning
• Risk Statements: H302-H312-H332
• Safety Statements: P261-P264-P270-P271-P280-P301+P317-P302+P352-P304+P340-P317-P321-P330-P362+P364-P501

Hazard Classification

Hazard	Class	Category Code	Hazard Statement
Acute toxicity	Acute Tox.	4	H312
Acute toxicity	Acute Tox.	4	H302
Acute toxicity	Acute Tox.	4	H332

Discovery and Applications

5-Oxa-2-octyne-1,7-diol is a bifunctional organic compound with an alkyne group and two hydroxyl groups located at opposite ends of its structure. This molecule, also known as a diol due to the presence of the two hydroxyl groups, has found various applications in the field of polymer chemistry, as well as in materials science. The discovery of 5-Oxa-2-octyne-1,7-diol was driven by the demand for functionalized molecules that could serve as crosslinkers and intermediates in the synthesis of complex polymers and advanced materials.

The structure of 5-Oxa-2-octyne-1,7-diol provides unique chemical reactivity due to the presence of the alkyne group, which is capable of undergoing a variety of addition reactions, such as click chemistry and cycloadditions. These reactions have enabled its use in the formation of crosslinked polymer networks, where the diol can act as a crosslinker, facilitating the formation of highly stable materials with enhanced mechanical properties. The hydroxyl groups on both ends of the molecule allow it to participate in esterification and etherification reactions, making it a versatile building block for the creation of polymeric chains and networks.

In materials science, 5-Oxa-2-octyne-1,7-diol has been utilized in the design of advanced coatings and adhesives. Its ability to form strong chemical bonds with other monomers has led to its incorporation into adhesives with high strength and durability. Additionally, the flexibility of its structure, combined with the reactivity of the alkyne and hydroxyl groups, makes it useful for modifying surface properties of materials, leading to enhanced adhesion and chemical resistance.

The compound's bifunctional nature has also attracted interest in biomedical applications. In particular, 5-Oxa-2-octyne-1,7-diol has been investigated for its potential use in the synthesis of biodegradable polymers and hydrogels, which are increasingly important in drug delivery and tissue engineering. The ability to control the polymerization process and create well-defined structures is critical for developing biocompatible materials, and the chemical versatility of this compound provides significant advantages in such applications.

References

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