Ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate
[CAS# 161798-03-4]

Identification

• Classification: Chemical reagent >> Organic reagent >> Ester >> Ethyl ester compound
• Name: Ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate
• Molecular Formula: C₁₈H₂₁NO₄S
• Molecular Weight: 347.43
• CAS Registry Number: 161798-03-4
• EC Number: 700-743-7
• SMILES: CCOC(=O)C1=C(N=C(S1)C2=CC(=C(C=C2)OCC(C)C)C=O)C

Properties

• Density: 1.183

Safety Data

• Hazard Symbols: GHS07 Warning
• Risk Statements: H315-H319
• Safety Statements: P264-P264+P265-P280-P302+P352-P305+P351+P338-P321-P332+P317-P337+P317-P362+P364

Hazard Classification

Hazard	Class	Category Code	Hazard Statement
Skin irritation	Skin Irrit.	2	H315
Eye irritation	Eye Irrit.	2	H319

Discovery and Applications

Ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate, commonly referred to as formyl-isobutoxyphenyl thiazole carboxylate, emerged from ongoing chemical research into thiazole derivatives. The compound was synthesized through efforts to functionalize thiazole rings with aldehyde and isobutoxyphenyl groups, leveraging the unique chemical reactivity of these moieties. Researchers combined 3-formyl-4-isobutoxybenzaldehyde with thioamide and ethyl chloroacetate in a multi-step reaction to obtain this novel compound. Its synthesis highlighted the potential of thiazole derivatives for creating new molecules with diverse biological and chemical properties, opening pathways for innovative applications in various fields including pharmaceuticals, materials science, and agrochemicals.

References

2020. Design, synthesis, cytotoxic evaluation and molecular docking studies of novel thiazolyl α-aminophosphonates. Research on Chemical Intermediates, 47(2), 567-583.
DOI: 10.1007/s11164-020-04321-6