Afatinib Impurity
[CAS# 1680184-59-1]

Identification

• Name: Afatinib Impurity
• Synonyms: (Z)-N-[4-(3-chloro-4-fluoroanilino)-7-[(3S)-oxolan-3-yl]oxyquinazolin-6-yl]-4-(dimethylamino)but-2-enamide
• Molecular Formula: C₂₄H₂₅ClFN₅O₃
• Molecular Weight: 485.94
• CAS Registry Number: 1680184-59-1
• SMILES: CN(C)C/C=CC(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)O[C@H]4CCOC4

Properties

• Density: 1.4±0.1 g/cm³, Calc.^*
• Index of Refraction: 1.668, Calc.^*
• Boiling Point: 676.9±55.0 °C (760 mmHg), Calc.^*
• Flash Point: 363.2±31.5 °C, Calc.^*

^* Calculated using Advanced Chemistry Development (ACD/Labs) Software.

Safety Data

• Hazard Symbols: GHS07 Warning
• Risk Statements: H302-H315-H319-H335
• Safety Statements: P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501