N-methoxy-N,1-dimethyl-4-Piperidinecarboxamide
[CAS# 215950-19-9]

Identification

• Classification: Organic raw materials >> Heterocyclic compound >> Piperidines
• Name: N-methoxy-N,1-dimethyl-4-Piperidinecarboxamide
• Molecular Formula: C₉H₁₈N₂O₂
• Molecular Weight: 186.25
• CAS Registry Number: 215950-19-9
• SMILES: CN1CCC(CC1)C(=O)N(C)OC

Properties

• Solubility: Soluble (22 g/L) (25 °C), Calc.^*
• Density: 1.041±0.06 g/cm³ (20 °C 760 Torr), Calc.^*
• Index of Refraction: 1.478, Calc.^*
• Boiling Point: 235.3±50.0 °C (760 mmHg), Calc.^*
• Flash Point: 96.1±30.1 °C, Calc.^*

^* Calculated using Advanced Chemistry Development (ACD/Labs) Software.

Safety Data

• Hazard Symbols: GHS07 Warning
• Risk Statements: H302-H315-H319-H335
• Safety Statements: P261-P305+P351+P338

Discovery and Applications

N-methoxy-N,1-dimethyl-4-piperidinecarboxamide is a chemical compound that has garnered attention in the field of organic chemistry and medicinal research due to its unique structure and potential applications. This molecule consists of a piperidine ring, a nitrogen atom with a methoxy group, and a carboxamide functional group. The combination of these functional groups suggests that the compound may interact with a variety of biological targets, which has led to its investigation in pharmaceutical research, particularly in areas involving enzyme inhibition and receptor modulation.

The discovery of N-methoxy-N,1-dimethyl-4-piperidinecarboxamide emerged from the ongoing search for novel compounds with diverse pharmacological properties. The piperidine ring is a versatile structural element commonly found in many biologically active molecules, including analgesics, antidepressants, and antihypertensive agents. The methoxy group attached to the nitrogen atom can enhance the compound's ability to cross biological membranes, potentially improving its bioavailability and pharmacokinetic properties.

One of the primary areas of interest in the research surrounding N-methoxy-N,1-dimethyl-4-piperidinecarboxamide is its potential as an enzyme inhibitor. Enzymes are critical in regulating various biochemical pathways, and inhibitors of specific enzymes have been developed as treatments for a range of diseases. The carboxamide functional group is known for its ability to interact with enzyme active sites, and the methoxy group could contribute to the compound's binding affinity, making it a promising candidate for further investigation in the context of drug discovery.

In addition to its potential as an enzyme inhibitor, N-methoxy-N,1-dimethyl-4-piperidinecarboxamide may also have applications in neurochemistry. The presence of the piperidine ring and the ability of the compound to interact with receptors in the central nervous system suggests that it could have effects on neurotransmitter systems. Compounds that influence neurotransmitter pathways are valuable in treating a variety of neurological conditions, including depression, anxiety, and neurodegenerative diseases such as Alzheimer's and Parkinson's diseases.

Furthermore, the methoxy group could enhance the compound's lipophilicity, potentially allowing it to penetrate the blood-brain barrier more effectively. This is a crucial property for molecules intended for use in the treatment of central nervous system disorders, where drug delivery to the brain is often a challenge. By improving the compound's ability to cross the blood-brain barrier, N-methoxy-N,1-dimethyl-4-piperidinecarboxamide could be developed into a therapeutic agent for various neurological and psychiatric conditions.

In summary, N-methoxy-N,1-dimethyl-4-piperidinecarboxamide is a promising chemical compound with potential applications in the fields of enzyme inhibition and neurochemistry. Its unique structure, featuring a piperidine ring, methoxy group, and carboxamide functional group, suggests that it may interact with biological targets in a manner that could be therapeutically beneficial. Ongoing research into its biological activity and pharmacokinetic properties will be essential in determining its suitability for clinical applications, particularly in the treatment of neurological and metabolic disorders.

References

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