(S)-(+)-2,2-Dimethyl-1,3-dioxolane-4-methanol
[CAS# 22323-82-6]

Identification

• Name: (S)-(+)-2,2-Dimethyl-1,3-dioxolane-4-methanol
• Synonyms: (+)-2,3-O-Isopropylidene-sn-glycerol; (S)-(+)-Solketal
• Molecular Formula: C₆H₁₂O₃
• Molecular Weight: 132.16
• CAS Registry Number: 22323-82-6
• EC Number: 244-910-8

Properties

• Density: 1.07
• Boiling point: 82-83 °C (14 mmHg)
• Refractive index: 1.433-1.435
• Flash point: 80 °C
• alpha: 11 ° (c=5, CH3OH)
• Water solubility: miscible

Safety Data

• Safety Statements: S24/25

Hazard Classification

Hazard	Class	Category Code	Hazard Statement
Specific target organ toxicity - single exposure	STOT SE	3	H335
Skin irritation	Skin Irrit.	2	H315
Eye irritation	Eye Irrit.	2	H319
Flammable liquids	Flam. Liq.	4	H227
Eye irritation	Eye Irrit.	2A	H319

Discovery and Applications

2022. 1-(6-Methylsalicyloyl)glycerol from stony coral-derived Micromonospora sp. The Journal of Antibiotics.
DOI: 10.1038/s41429-022-00578-8

2020. Stereoselective 1,4-Addition of Primary Alcohols to γ-Alkoxy-α,β-unsaturated Esters. Synthesis.
DOI: 10.1055/s-0040-1707274

2015. Intramolecular Enantiomerism in S(+)2,2-dimethyl -1,3-dioxolane-4-methanol: The Interpretation of Raman Optical Activity Intensity. Chirality.
DOI: 10.1002/chir.22507