alpha-Iodo-4'-methylpropiophenone
[CAS# 236117-38-7]

Identification

• Classification: Chemical reagent >> Organic reagent >> Aromatic ketone
• Name: alpha-Iodo-4'-methylpropiophenone
• Synonyms: 2-Iodo-1-(4-methylphenyl)-1-propanone
• Molecular Formula: C₁₀H₁₁IO
• Molecular Weight: 274.10
• CAS Registry Number: 236117-38-7
• SMILES: CC1C=CC(=CC=1)C(=O)C(C)I

Properties

• Solubility: Very slightly soluble (0.27 g/L) (25 °C), Calc.^*
• Density: 1.6±0.1 g/cm³, Calc.^*
• Index of Refraction: 1.594, Calc.^*
• Boiling Point: 310.5±25.0 °C (760 mmHg), Calc.^*
• Flash Point: 141.6±23.2 °C, Calc.^*

^* Calculated using Advanced Chemistry Development (ACD/Labs) Software.

Discovery and Applications

Alpha-Iodo-4'-methylpropiophenone, a halogenated ketone compound, was discovered through organic chemistry research aimed at synthesizing novel intermediates and building blocks for organic synthesis. The synthesis typically involves the iodination of 4'-methylpropiophenone, resulting in the introduction of an iodine atom at the alpha position of the ketone functional group. Its discovery marked a significant advancement in synthetic chemistry, providing chemists with a versatile building block for creating molecules with diverse applications in pharmaceuticals, agrochemicals, materials science, and other fields.

Alpha-Iodo-4'-methylpropiophenone serves as a valuable intermediate in organic synthesis, facilitating the production of various chemical compounds with diverse applications. Its incorporation into multistep synthesis pathways enables the creation of complex molecules used in pharmaceuticals, agrochemicals, and materials science. Chemists exploit its reactivity and versatility to design efficient synthetic routes for producing target molecules, thereby advancing the development of new materials and chemical processes.

Alpha-Iodo-4'-methylpropiophenone is utilized in the synthesis of pharmaceutical compounds as a key intermediate. Its unique structure and reactivity make it a versatile building block for the production of various drugs, including analgesics, antihypertensives, and anticonvulsants. Chemical modifications of the ketone group enable the creation of drug candidates with improved efficacy, bioavailability, or selectivity, contributing to the development of new therapeutic treatments for various medical conditions.

In the agricultural sector, Alpha-Iodo-4'-methylpropiophenone finds application as a precursor for the synthesis of agrochemicals and pesticides. Ketone derivatives possess pesticidal properties and can be modified to enhance their effectiveness against pests, weeds, and fungal pathogens. By incorporating Alpha-Iodo-4'-methylpropiophenone into pesticide formulations, researchers aim to develop products that can protect crops from damage caused by insects, fungi, and other pests, thereby improving agricultural yields and food security.

Alpha-Iodo-4'-methylpropiophenone derivatives are utilized in materials science for the synthesis of functional materials with tailored properties. Chemical modifications of the ketone group enable the incorporation of Alpha-Iodo-4'-methylpropiophenone into polymers, coatings, and nanoparticles, imparting specific characteristics such as adhesion, conductivity, and optical properties. These materials find applications in diverse areas such as electronics, aerospace, and biotechnology, where precise control over material properties is essential for desired performance outcomes.

Beyond its established applications, ongoing research explores new uses for Alpha-Iodo-4'-methylpropiophenone in fields such as medicinal chemistry, catalysis, and drug discovery. Scientists investigate its reactivity, properties, and potential interactions with biological targets to develop innovative therapies for treating diseases and disorders. Additionally, advancements in synthetic methodologies and chemical synthesis techniques continue to expand the utility of this compound in diverse scientific and industrial applications.

References

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