Azelamide monoethanolamine
[CAS# 242132-61-2]

Identification

• Classification: Organic raw materials >> Alcohols, phenols, phenolic compounds and derivatives >> Acyclic alcohol
• Name: Azelamide monoethanolamine
• Synonyms: 9-(2-hydroxyethylamino)-9-oxononanoic acid
• Molecular Formula: C₁₁H₂₁NO₄
• Molecular Weight: 231.29
• CAS Registry Number: 242132-61-2
• EC Number: 881-290-3
• SMILES: C(CCCC(=O)NCCO)CCCC(=O)O

Properties

• Density: 1.1±0.1 g/cm³, Calc.^*
• Index of Refraction: 1.486, Calc.^*
• Boiling Point: 490.1±30.0 °C (760 mmHg), Calc.^*
• Flash Point: 250.2±24.6 °C, Calc.^*

^* Calculated using Advanced Chemistry Development (ACD/Labs) Software.

Safety Data

• Hazard Symbols: GHS0i7 Warning
• Risk Statements: H302-H315-H319-H335
• Safety Statements: P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501

Discovery and Applications

Azelaic acid monoethanolamide, also known as azelaic acid monoethanolamide or simply azelaic acid, is a derivative of azelaic acid and ethanolamine. It is synthesized by reacting azelaic acid with monoethanolamine. The discovery of azelaic acid monoethanolamine stems from research into the biological activity of azelaic acid, a naturally occurring dicarboxylic acid found in various grains such as barley, wheat, and rye. Azelaic acid is an ingredient in skin care products for conditions such as acne, rosacea, and hyperpigmentation due to its anti-inflammatory, antimicrobial, and antioxidant properties. Azelaic acid monoethanolamine was developed as a derivative of azelaic acid to enhance its solubility and stability in cosmetic formulations. As a multifunctional ingredient, azelaic acid monoethanolamine offers a variety of benefits for skin care. Azelaic acid monoethanolamine has anti-inflammatory properties and is effective in reducing redness, swelling, and irritation associated with inflammatory skin conditions such as acne and rosacea. Azelaic acid monoethanolamine has antimicrobial activity against acne-causing bacteria such as Propionibacterium acnes, making it an effective ingredient for treating acne and preventing bacterial growth on the skin surface. Azelaic acid monoethanolamine acts as an antioxidant, protecting the skin from oxidative stress caused by environmental factors such as UV radiation, pollution, and free radicals. It helps neutralize harmful molecules and prevent premature aging of the skin. Azelaic acid monoethanolamine acts as a skin conditioning agent, helping to moisturize, soften, and smooth the skin texture. Azelaic acid monoethanolamine can also be used in other industries, including pharmaceuticals and personal care products. Its multifunctional properties make it a versatile ingredient for formulating a variety of products, from topical treatments for skin conditions to hair care products and oral hygiene products.

References

2018.The Chemical and Products Database, a resource for exposure-relevant data on chemicals in consumer products, Scientific Data, volume 5, Article number: 180125.
DOI: 10.1038/sdata.2018.125

EUCOSMETICS Combined Inventory of Ingredients Employed in Cosmetic Products (2000) and Revised Inventory (2006).
DOI: 10.5281/zenodo.2624118