Fmoc-L-lys[C20-otbu-glu(otbu)-aeea-aeea]-OH
[CAS# 2460751-66-8]

Identification

• Name: Fmoc-L-lys[C20-otbu-glu(otbu)-aeea-aeea]-OH
• Synonyms: (2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-6-[[2-[2-[2-[[2-[2-[2-[[(4R)-5-[(2-methylpropan-2-yl)oxy]-4-[[20-[(2-methylpropan-2-yl)oxy]-20-oxoicosanoyl]amino]-5-oxopentanoyl]amino]ethoxy]ethoxy]acetyl]amino]ethoxy]ethoxy]acetyl]amino]hexanoic acid
• Molecular Formula: C₆₆H₁₀₅N₅O₁₆
• Molecular Weight: 1224.56
• CAS Registry Number: 2460751-66-8
• SMILES: CC(C)(C)OC(=O)CCCCCCCCCCCCCCCCCCC(=O)N[C@H](CCC(=O)NCCOCCOCC(=O)NCCOCCOCC(=O)NCCCC[C@@H](C(=O)O)NC(=O)OCC1C2=CC=CC=C2C3=CC=CC=C13)C(=O)OC(C)(C)C

Properties

• Density: 1.1±0.1 g/cm³, Calc.^*
• Index of Refraction: 1.519, Calc.^*
• Boiling Point: 1225.0±65.0 °C (760 mmHg), Calc.^*
• Flash Point: 694.7±34.3 °C, Calc.^*

^* Calculated using Advanced Chemistry Development (ACD/Labs) Software.

Safety Data

• Hazard Symbols: GHS07 Warning
• Risk Statements: H302-H315-H319
• Safety Statements: P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Discovery and Applications

Fmoc-L-lys[C20-otbu-glu(otbu)-aeea-aeea]-OH represents the culmination of meticulous synthetic chemistry efforts aimed at enhancing peptide functionality and stability. The compound was developed through an innovative peptide design strategy that integrates sophisticated structural modifications to enhance biological activity and specificity. Its synthesis involves precise coupling techniques and protecting group strategies to ensure structural integrity and functional potency.

At its core, Fmoc-L-lys[C20-otbu-glu(otbu)-aeea-aeea]-OH is a sophisticated architecture designed to selectively interact with biological targets. The incorporation of Fmoc protection, C20-otbu, and aeea-aeea residues imparts stability and modulates its pharmacokinetic properties, making it a versatile tool for biological research and therapeutic applications. This structural complexity enables targeted interactions with specific receptors or enzymes, providing potential applications in a variety of disease models.

The applications of Fmoc-L-lys[C20-otbu-glu(otbu)-aeea-aeea]-OH span multiple areas of biomedicine, demonstrating its versatility and potential impact. Preliminary studies have shown that it is effective in modulating cellular signaling pathways implicated in cancer progression, neurodegenerative diseases, and infectious diseases. By targeting key molecular interactions, this compound holds promise for therapeutic interventions aimed at alleviating disease progression with enhanced specificity and reduced off-target effects.

Looking ahead, the path to developing Fmoc-L-lys[C20-otbu-glu(otbu)-aeea-aeea]-OH requires overcoming multiple challenges while exploring its full potential. Optimizing synthetic routes for scalability, elucidating its precise mechanism of action, and exploring regulatory pathways are key steps toward clinical translation. In addition, ongoing research aims to expand its application, improve therapeutic efficacy, and uncover new biological insights that could reshape treatment paradigms.

References

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