Tolevamer
[CAS# 28210-41-5]

Identification

• Classification: Catalysts and additives >> Polymer
• Name: Tolevamer
• Synonyms: 4-Vinylbenzenesulfonic acid homopolymer; 4-Ethenylbenzenesulfonic acid homopolymer
• Molecular Formula: (C₈H₈O₃S)_n
• CAS Registry Number: 28210-41-5
• EC Number: 639-922-9
• SMILES: c1ccc2c(c1)ccc(c2O)[N+](=O)[O-]

Properties

• Density: 1.4±0.1 g/cm³, Calc.^*
• Metlting Point: 123-125 °C (Expl.)
• Index of Refraction: 1.714, Calc.^*
• Boiling Point: 336.7±15.0 °C (760 mmHg), Calc.^*
• Flash Point: 149.9±8.8 °C, Calc.^*

^* Calculated using Advanced Chemistry Development (ACD/Labs) Software.

Safety Data

• Hazard Symbols: GHS05 Danger
• Risk Statements: H314
• Safety Statements: P280-P305+P351+P338-P310

Hazard Classification

Hazard	Class	Category Code	Hazard Statement
Skin corrosion	Skin Corr.	1A	H314
Acute toxicity	Acute Tox.	3	H331
Skin corrosion	Skin Corr.	1B	H314
Serious eye damage	Eye Dam.	1	H318

Discovery and Applications

Tolevamer is a chemical substance that has gained significant attention in the field of medicine and pharmaceuticals due to its role as a treatment for certain gastrointestinal disorders. It is primarily known for its use as a non-absorbable polymer that is effective in the treatment of irritable bowel syndrome (IBS) and other gastrointestinal conditions. Tolevamer is a polyether-based compound, characterized by its ability to form a gel-like structure in the intestines, which helps to protect the gut lining and relieve symptoms associated with digestive disorders.

The discovery of tolevamer was driven by the need for a drug that could manage gastrointestinal disorders without the need for systemic absorption. It was developed as a polymer with high molecular weight, ensuring that it remains localized within the digestive tract. The structure of tolevamer consists of repeating units that contribute to its non-absorbable nature, allowing it to function effectively as a treatment for conditions like IBS without affecting the rest of the body.

In terms of its applications, tolevamer is most commonly used in the treatment of IBS, particularly in cases where patients experience symptoms such as abdominal pain, bloating, and irregular bowel movements. The compound works by forming a gel in the intestines, which acts as a protective barrier against irritating substances. This gel-like structure helps to alleviate discomfort and reduce inflammation in the gut. Tolevamer is also sometimes used in the management of diarrhea associated with IBS, as its properties help to control fluid balance within the intestines.

In addition to its use in treating IBS, tolevamer has been explored for its potential in managing other gastrointestinal conditions, such as inflammatory bowel disease (IBD) and acid reflux. Researchers have also investigated its use in promoting gut health and improving the overall function of the digestive system. Its non-absorbable nature makes it a particularly attractive option for long-term use, as it does not lead to systemic side effects or interactions with other medications.

Tolevamer’s applications extend beyond the clinical setting as well. It has been studied for use in animal feed to improve digestive health in livestock. Its properties as a gut protectant make it a useful additive in agricultural settings, where it can help manage digestive issues in animals and improve overall health outcomes.

In conclusion, tolevamer is an important chemical compound that has found applications in the treatment of gastrointestinal disorders, particularly in the management of irritable bowel syndrome. Its non-absorbable, gel-forming properties make it an effective and safe option for patients seeking relief from digestive issues, without the risks associated with systemic absorption.

References

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