3-Aminopropylmethyldiethoxysilane
[CAS# 3179-76-8]

Identification

• Classification: Chemical reagent >> Organic reagent >> Siloxane
• Name: 3-Aminopropylmethyldiethoxysilane
• Synonyms: 3-Aminopropyl(diethoxy)methylsilane; 3-(Diethoxymethylsilyl)propylamine; 3-Aminopropyl-methyl-diethoxysilane
• Molecular Formula: C₈H₂₁NO₂Si
• Molecular Weight: 191.34
• CAS Registry Number: 3179-76-8
• EC Number: 221-660-8
• SMILES: CCO[Si](C)(CCCN)OCC

Properties

• Density: 0.916
• Boiling point: 85-88 °C
• Refractive index: 1.426
• Flash point: 75.5 °C

Safety Data

• Hazard Symbols: GHS05 Danger
• Risk Statements: H314-H318
• Safety Statements: P260-P261-P264-P264+P265-P271-P280-P301+P330+P331-P302+P361+P354-P304+P340-P305+P354+P338-P316-P317-P319-P321-P363-P403+P233-P405-P501

Hazard Classification

Hazard	Class	Category Code	Hazard Statement
Skin corrosion	Skin Corr.	1B	H314
Serious eye damage	Eye Dam.	1	H318
Chronic hazardous to the aquatic environment	Aquatic Chronic	3	H412

• Transport Information: UN 3267

Discovery and Applications

3-Aminopropylmethyldiethoxysilane is an organosilicon compound that has gained significant attention due to its unique chemical properties and diverse applications in various fields, particularly in surface modification, coatings, and adhesion technologies. The discovery of this compound is rooted in the exploration of silane chemistry, which has been a crucial area of study since the mid-20th century. Silanes are recognized for their ability to form strong chemical bonds with inorganic materials, enhancing the properties of composites and other materials.

The synthesis of 3-aminopropylmethyldiethoxysilane typically involves the reaction of chlorosilanes with amines in the presence of an alcohol. In this case, 3-aminopropyl groups are introduced alongside methyldiethoxysilane, resulting in a compound that combines the properties of both organic amines and silanes. This specific structure enables the compound to function as a coupling agent, promoting adhesion between organic polymers and inorganic substrates such as glass, metals, and ceramics.

One of the primary applications of 3-aminopropylmethyldiethoxysilane is in the field of coatings and sealants. Its ability to enhance adhesion properties makes it particularly valuable in formulations where the bonding of organic and inorganic materials is required. For instance, in the production of paints and coatings, the inclusion of this silane can significantly improve the durability and weather resistance of the final product. This is particularly important in applications involving outdoor exposure, where coatings must withstand environmental stressors such as moisture, UV radiation, and temperature fluctuations.

Additionally, 3-aminopropylmethyldiethoxysilane is widely used in the development of composite materials. By incorporating this silane into polymer matrices, manufacturers can improve the mechanical properties and performance of composites, making them suitable for applications in the automotive, aerospace, and construction industries. The silane acts as a bridge, enhancing the interface between the inorganic filler and the organic polymer, which results in improved tensile strength, impact resistance, and thermal stability.

In the realm of biotechnology, 3-aminopropylmethyldiethoxysilane has shown promise as a surface modification agent for various substrates, including biosensors and biomedical devices. Its amino groups facilitate the attachment of biomolecules, allowing for the development of functionalized surfaces that can be utilized in diagnostics, drug delivery, and tissue engineering. The ability to create bioactive surfaces is essential for advancing research in these fields, as it can lead to improved interactions between materials and biological systems.

Despite its numerous applications, safety considerations are crucial when handling 3-aminopropylmethyldiethoxysilane. As with many silanes, proper safety protocols should be followed to minimize exposure, as inhalation or skin contact can cause irritation. Regulatory agencies evaluate the safety of such compounds to ensure they meet necessary health and environmental standards.

In conclusion, 3-aminopropylmethyldiethoxysilane is a versatile organosilicon compound with significant applications in coatings, composites, and biotechnology. Its unique chemical structure allows for enhanced adhesion and surface modification, making it an invaluable component in various industrial processes. As research continues to explore its potential, 3-aminopropylmethyldiethoxysilane is poised to play an essential role in advancing materials science and engineering.

References

2023. An experimental study using 3-aminoproplymethyldiethoxysilane (APMDS) to improve biocompatibility of NR latex film. Journal of Rubber Research, 26(3).
DOI: 10.1007/s42464-023-00200-y

2018. Strengthening naturally and artificially aged paper using polyaminoalkylalkoxysilane copolymer networks. Cellulose, 25(10).
DOI: 10.1007/s10570-018-1955-4

2016. Chemical-physical characterization of ancient paper with functionalized polyamidoamines (PAAs). Cellulose, 24(2).
DOI: 10.1007/s10570-016-1159-8