2-(Methylamino)pyridine-3-methanol
[CAS# 32399-12-5]

Identification

• Classification: Pharmaceutical intermediate >> Heterocyclic compound intermediate >> Pyridine compound >> Pyridine derivative
• Name: 2-(Methylamino)pyridine-3-methanol
• Synonyms: [2-(Methylamino)-3-pyridyl]methanol
• Molecular Formula: C₇H₁₀N₂O
• Molecular Weight: 138.17
• CAS Registry Number: 32399-12-5
• EC Number: 692-124-2
• SMILES: CNC1=C(C=CC=N1)CO

Properties

• Density: 1.2±0.1 g/cm³, Calc.^*
• Index of Refraction: 1.614, Calc.^*
• Boiling Point: 312.2±32.0 °C (760 mmHg), Calc.^*
• Flash Point: 142.6±25.1 °C, Calc.^*

^* Calculated using Advanced Chemistry Development (ACD/Labs) Software.

Safety Data

• Hazard Symbols: GHS05;GHS07 Danger
• Risk Statements: H302-H315-H318-H335
• Safety Statements: P261-P264-P264+P265-P270-P271-P280-P301+P317-P302+P352-P304+P340-P305+P354+P338-P317-P319-P321-P330-P332+P317-P362+P364-P403+P233-P405-P501

Hazard Classification

Hazard	Class	Category Code	Hazard Statement
Serious eye damage	Eye Dam.	1	H318
Skin irritation	Skin Irrit.	2	H315
Specific target organ toxicity - single exposure	STOT SE	3	H335
Acute toxicity	Acute Tox.	4	H302

Discovery and Applications

2-(Methylamino)pyridine-3-methanol, a chemical compound with the molecular formula C7H10N2O, is a derivative of pyridine that features both a methylamino group and a hydroxymethyl group attached to the aromatic ring. This compound has garnered attention due to its unique structural properties, which give it potential applications in various fields, including medicinal chemistry, chemical synthesis, and material science.

The discovery of 2-(Methylamino)pyridine-3-methanol can be traced back to the ongoing exploration of pyridine derivatives and their diverse chemical properties. Pyridine itself, a heterocyclic compound, has been a staple in organic chemistry since its first isolation in the early 19th century. The introduction of substituents such as methylamino and hydroxymethyl groups onto the pyridine ring has been a subject of study to explore the effects these modifications have on the molecule’s reactivity and biological activity.

In terms of applications, 2-(Methylamino)pyridine-3-methanol holds particular promise in medicinal chemistry. Its structure, containing both an amino group and a hydroxymethyl group, makes it a potential candidate for designing bioactive molecules. The methylamino group is known for its ability to interact with biological systems, while the hydroxymethyl group can act as a point for further modification or conjugation with other bioactive entities. As a result, compounds like 2-(Methylamino)pyridine-3-methanol are studied for their potential as drug intermediates or for use in the development of therapeutics targeting various diseases.

One of the main uses of 2-(Methylamino)pyridine-3-methanol is as a building block in the synthesis of more complex chemical structures. Due to its functional groups, it can participate in a variety of organic reactions, including nucleophilic substitutions and condensation reactions. The presence of the hydroxymethyl group also suggests that the compound could be involved in cross-coupling reactions or act as a ligand in coordination chemistry. This versatility makes it an attractive reagent in synthetic chemistry.

Another area of interest is the exploration of 2-(Methylamino)pyridine-3-methanol as a potential intermediate in the creation of new materials. Pyridine derivatives are often used in the design of organic semiconductors, ligands for metal coordination, and other functional materials. The compound’s ability to coordinate with metal ions could make it useful in the development of catalytic systems or in material applications where pyridine-based ligands are required.

Despite its potential, 2-(Methylamino)pyridine-3-methanol remains a subject of ongoing research, and its commercial applications are still being explored. Like many compounds with reactive functional groups, it requires careful handling, and its toxicity and environmental impact must be studied to ensure its safe use in any application.

In conclusion, 2-(Methylamino)pyridine-3-methanol is an important compound in the field of organic chemistry, with potential applications in medicinal chemistry, materials science, and synthetic chemistry. Its structural features make it an attractive candidate for further research, particularly in the development of new drugs or materials. As research progresses, the compound’s full range of applications and potential benefits will continue to unfold, marking it as a valuable building block in chemical synthesis and drug development.

References

none