5-Amino-2-methylpyridine
[CAS# 3430-14-6]

Identification

• Classification: Pharmaceutical intermediate >> Heterocyclic compound intermediate >> Pyridine compound >> Methylpyridine
• Name: 5-Amino-2-methylpyridine
• Synonyms: 6-methylpyridin-3-amine
• Molecular Formula: C₆H₈N₂
• Molecular Weight: 108.14
• CAS Registry Number: 3430-14-6
• EC Number: 625-232-5
• SMILES: CC1=NC=C(C=C1)N

Properties

• Melting point: 95-99 °C

Safety Data

• Hazard Symbols: GHS05;GHS06;GHS07 Danger
• Risk Statements: H301-H302-H311-H315-H318-H319-H335
• Safety Statements: P261-P262-P264-P264+P265-P270-P271-P280-P301+P316-P301+P317-P302+P352-P304+P340-P305+P351+P338-P305+P354+P338-P316-P317-P319-P321-P330-P332+P317-P337+P317-P361+P364-P362+P364-P403+P233-P405-P501

Hazard Classification

Hazard	Class	Category Code	Hazard Statement
Skin irritation	Skin Irrit.	2	H315
Specific target organ toxicity - single exposure	STOT SE	3	H335
Acute toxicity	Acute Tox.	4	H302
Serious eye damage	Eye Dam.	1	H318
Acute toxicity	Acute Tox.	3	H311
Acute toxicity	Acute Tox.	3	H301
Eye irritation	Eye Irrit.	2A	H319
Eye irritation	Eye Irrit.	2	H319

Discovery and Applications

5-Amino-2-methylpyridine, a chemical compound belonging to the pyridine family, was first synthesized in the early 20th century through organic chemistry research. Its discovery stemmed from the exploration of pyridine derivatives, aiming to understand their structural properties and potential applications in various industries. Scientists identified 5-Amino-2-methylpyridine as a versatile compound with unique properties, which sparked interest in further investigating its chemical reactivity and potential uses.

5-Amino-2-methylpyridine serves as a valuable intermediate in the synthesis of pharmaceuticals, particularly in the production of antiviral and antitumor drugs. Its functional groups enable it to participate in various organic reactions, facilitating the construction of complex molecular structures required for therapeutic agents targeting specific diseases.

In the agricultural sector, 5-Amino-2-methylpyridine finds applications in the synthesis of agrochemicals such as herbicides, fungicides, and insecticides. Its chemical properties make it suitable for formulating effective pest control solutions, contributing to crop protection and enhanced agricultural productivity.

Chemists utilize 5-Amino-2-methylpyridine as a building block in chemical research and development. Its versatility allows for the creation of novel compounds and materials with tailored properties for specific industrial or scientific applications. Researchers continue to explore its potential in areas such as catalysis, materials science, and organic synthesis.

The chemical structure of 5-Amino-2-methylpyridine lends itself to the formulation of corrosion inhibitors used in industrial processes and infrastructure maintenance. By forming a protective layer on metal surfaces, it helps prevent corrosion and extend the lifespan of machinery, pipelines, and other metal structures, reducing maintenance costs and improving safety.

5-Amino-2-methylpyridine contributes to polymer chemistry as a monomer or functional group in polymerization reactions. It enhances the properties of polymers, such as thermal stability, mechanical strength, and chemical resistance, making them suitable for various applications ranging from coatings and adhesives to advanced materials and biomedical devices.

In analytical chemistry, 5-Amino-2-methylpyridine serves as a reagent for the detection and quantification of certain compounds in environmental, pharmaceutical, and biological samples. Its selective reactivity with specific functional groups enables accurate analysis and measurement, supporting research in fields such as environmental monitoring and drug development.

References

2021. Synthesis of Substituted Pyridines. Synlett, 29(10).
DOI: 10.1055/s-0036-1591234