1-Butylpyrrolidin-2-one
[CAS# 3470-98-2]

Identification

• Classification: Pharmaceutical intermediate >> Heterocyclic compound intermediate >> Pyrimidine compound >> Ketones
• Name: 1-Butylpyrrolidin-2-one
• Molecular Formula: C₈H₁₅NO
• Molecular Weight: 141.21
• CAS Registry Number: 3470-98-2
• EC Number: 222-437-8
• SMILES: CCCCN1CCCC1=O

Safety Data

• Hazard Symbols: GHS07 Warning
• Risk Statements: P261-P264-P264+P265-P270-P271-P280-P301+P317-P302+P352-P304+P340-P305+P351+P338-P319-P321-P330-P332+P317-P337+P317-P362+P364-P403+P233-P405-P501

Hazard Classification

Hazard	Class	Category Code	Hazard Statement
Skin irritation	Skin Irrit.	2	H315
Eye irritation	Eye Irrit.	2	H319
Acute toxicity	Acute Tox.	4	H302
Specific target organ toxicity - single exposure	STOT SE	3	H335
Eye irritation	Eye Irrit.	2A	H319

Discovery and Applications

N1-Butylpyrrolidin-2-one, often abbreviated as NBP, is a chemical compound of significant interest in both industrial and research contexts. Discovered in the mid-20th century, this compound has garnered attention for its unique chemical properties and versatile applications. NBP is a cyclic amide with a butyl group attached to the nitrogen of the pyrrolidinone ring, making it a member of the pyrrolidone family.

The compound was first synthesized in the 1960s as part of research into new organic solvents and reagents. Early studies focused on its potential as a solvent due to its ability to dissolve a range of organic and inorganic materials. The structure of NBP, featuring a pyrrolidinone ring, provides it with properties that make it suitable for various industrial applications.

One of the primary applications of N1-Butylpyrrolidin-2-one is as a solvent in the chemical industry. Its ability to dissolve a wide range of substances makes it useful in processes such as polymer production, where it can help in the dissolution of polymers and other materials that are otherwise difficult to handle. NBP’s high boiling point and stability contribute to its effectiveness in these applications, allowing for efficient processing and formulation.

In addition to its role as a solvent, NBP is used in the synthesis of pharmaceuticals and fine chemicals. Its properties make it an ideal candidate for use in drug development and manufacturing. NBP is employed as a reagent in various chemical reactions, facilitating the creation of complex molecules and enhancing the efficiency of synthesis processes. This application is particularly important in the pharmaceutical industry, where NBP helps improve the solubility and bioavailability of active ingredients.

Furthermore, N1-Butylpyrrolidin-2-one has applications in the field of materials science. It is used in the formulation of specialty coatings and adhesives, where its solvent properties enhance the performance and durability of the final products. NBP’s ability to interact with different materials and improve their properties makes it valuable in the development of advanced materials.

The compound’s safety profile is generally favorable, but like many chemicals, it requires proper handling and safety measures to avoid potential hazards. Standard safety protocols should be followed, including the use of protective equipment and proper ventilation, to ensure safe use in industrial and laboratory settings.

In summary, N1-Butylpyrrolidin-2-one is a versatile chemical with important applications in various industries. From its discovery as a solvent to its current use in pharmaceuticals and materials science, NBP’s unique properties make it an essential component in chemical processing and product development.

References

2022. A comprehensive review on the synthesis of 2-pyrrolidone and N-alkyl-2-pyrrolidones: from fundamental research to industrial applications. Green Chemistry, 24(5).
DOI: 10.1039/D1GC0466A