N-Sulfo-glucosamine sodium salt
[CAS# 38899-05-7]

Identification

• Classification: Biochemical >> Carbohydrate >> Monosaccharide
• Name: N-Sulfo-glucosamine sodium salt
• Synonyms: 2-Deoxy-2-sulfoamino-D-glucose sodium salt; 2-Deoxy-2-(sulfoamino)-D-glucose monosodium salt
• Molecular Formula: C₆H₁₂NNaO₈S
• Molecular Weight: 281.22
• CAS Registry Number: 38899-05-7
• EC Number: 609-596-2
• SMILES: C([C@H]([C@H]([C@@H]([C@H](C=O)NS(=O)(=O)[O-])O)O)O)O.[Na+]

Safety Data

• Hazard Symbols: GHS07 Warning
• Risk Statements: H302-H315-H319-H335
• Safety Statements: H302-H315-H319-H335

Discovery and Applications

N-Sulfo-glucosamine sodium salt is a chemical compound that is derived from glucosamine, an amino sugar that plays a key role in the structure of glycosaminoglycans and proteoglycans. It is a derivative of glucosamine where a sulfonate group is attached to the nitrogen of the glucosamine molecule. The sodium salt form of N-sulfo-glucosamine is commonly used in scientific research and has applications in various fields, including pharmaceutical development, biochemistry, and the study of cell biology.

The compound is often synthesized through the sulfonation of glucosamine, a process that adds a sulfonic acid group (-SO₃Na) to the glucosamine molecule. This modification alters the properties of glucosamine and can enhance its solubility and biological activity in certain applications. N-Sulfo-glucosamine sodium salt is typically used in studies related to cellular processes, particularly in the areas of cell signaling, cartilage repair, and joint health.

N-Sulfo-glucosamine sodium salt is mainly studied for its potential to influence the synthesis of glycosaminoglycans, which are important components of the extracellular matrix in connective tissues such as cartilage. The sulfation of glucosamine can enhance the biological functions of glucosamine, especially in promoting the repair of damaged tissues and supporting joint health. It has been investigated in the context of osteoarthritis treatment, as glucosamine derivatives are commonly explored for their ability to promote cartilage repair and reduce inflammation in the joints.

In addition to its use in studying cartilage biology, N-sulfo-glucosamine sodium salt is sometimes employed in laboratory research to explore the molecular mechanisms of cell adhesion and signaling. Its modified structure makes it a useful tool for understanding the interactions between cells and the extracellular matrix, which is crucial for tissue regeneration and repair processes.

Moreover, the compound has been explored in the context of drug development, particularly for diseases involving connective tissue and joint degeneration. Its potential role in modifying the structure and function of the extracellular matrix has led to its investigation as a potential therapeutic agent for conditions like osteoarthritis, where the breakdown of cartilage contributes to pain and disability.

While the compound is not widely used in commercial pharmaceutical products, its applications in research have contributed to a greater understanding of glycosaminoglycans and their role in health and disease. It is also of interest to the biochemistry and pharmacology communities for its structural properties and its ability to modify the biological activity of glucosamine and other related compounds.

In summary, N-sulfo-glucosamine sodium salt is a chemical derivative of glucosamine that plays an important role in the study of cell biology, joint health, and tissue repair. Its use in research is primarily focused on understanding its effects on the extracellular matrix, cartilage regeneration, and potential therapeutic applications for conditions like osteoarthritis. Through its impact on glucosamine's properties, N-sulfo-glucosamine sodium salt has provided valuable insights into the mechanisms of cellular interaction and the maintenance of connective tissue health.

References

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