L-Arginine L-glutamate
[CAS# 4320-30-3]

Identification

• Classification: Biochemical >> Amino acids and their derivatives >> Arginine derivatives
• Name: L-Arginine L-glutamate
• Synonyms: (2S)-2-amino-5-(diaminomethylideneamino)pentanoic acid;(2S)-2-aminopentanedioic acid
• Molecular Formula: C₆H₁₄N₄O₂.C₅H₉NO₄
• Molecular Weight: 321.33
• CAS Registry Number: 4320-30-3
• EC Number: 224-350-0
• SMILES: C(C[C@@H](C(=O)O)N)CN=C(N)N.C(CC(=O)O)[C@@H](C(=O)O)N

Safety Data

• Hazard Symbols: GHS07 Warning
• Risk Statements: H302-H315-H319-H335
• Safety Statements: P261-P264-P264+P265-P270-P271-P280-P301+P317-P302+P352-P304+P340-P305+P351+P338-P319-P321-P330-P332+P317-P337+P317-P362+P364-P403+P233-P405-P501

Hazard Classification

Hazard	Class	Category Code	Hazard Statement
Specific target organ toxicity - single exposure	STOT SE	3	H335
Skin irritation	Skin Irrit.	2	H315
Acute toxicity	Acute Tox.	4	H302
Eye irritation	Eye Irrit.	2A	H319

Discovery and Applications

L-Arginine L-Glutamate is a salt formed by the ionic interaction between the positively charged amino acid L-arginine and the negatively charged amino acid L-glutamate. It was originally identified and synthesized by chemical methods designed to combine the two amino acids in a stable form.

L-Arginine L-Glutamate is composed of one L-arginine molecule and one L-glutamate molecule connected by ionic bonds. The molecular structure facilitates its solubility in water, allowing it to be bioavailable for physiological processes.

L-Arginine is a precursor for the synthesis of nitric oxide (NO) in the body. NO is an important signaling molecule involved in vasodilation, immune response, and neurotransmission. By providing L-arginine in a bioavailable form, L-Arginine L-Glutamate supports NO production, which helps regulate blood flow and cardiovascular health. Both L-Arginine and L-Glutamate are essential amino acids involved in protein synthesis. L-Arginine plays an important role in wound healing, immune function, and hormone secretion, while L-Glutamate aids in neurotransmission and metabolic processes.

L-Arginine L-Glutamate is commonly used as a dietary supplement to enhance athletic performance, support cardiovascular health, and promote overall well-being. Its role in NO production makes it popular among athletes and individuals seeking to improve circulation and muscle function. In clinical settings, L-Arginine L-Glutamate can be used to treat patients with cardiovascular conditions, such as hypertension or angina, to improve blood flow and reduce symptoms. It has also been studied for its potential efficacy in treating erectile dysfunction and peripheral vascular disease, among other conditions.

Research continues to explore the therapeutic potential of L-Arginine L-Glutamate for a variety of medical conditions. Studies have investigated its effects on vascular health, immune function, and metabolic disorders, with the goal of elucidating its mechanisms of action and optimizing treatment strategies. L-Arginine L-Glutamate is formulated into different pharmaceutical formulations, including tablets, capsules, and powders, to ensure precise dosing and bioavailability. These formulations are designed to provide optimal concentrations of L-Arginine and L-Glutamate for specific health benefits.

References

1964. Arginine glutamate in the treatment of hepatic coma. The American Journal of Medicine, 36(5).
DOI: 10.1016/0002-9343(64)90183-7

2022. Effects of arginine glutamate (RE:pair) on wound healing and skin elasticity improvement after CO2 laser irradiation. Journal of Cosmetic Dermatology, 21(12).
DOI: 10.1111/jocd.14957