Hostacor H
[CAS# 46948-72-5]

Identification

• Classification: Pharmaceutical intermediate >> Heterocyclic compound intermediate >> Pyrimidine compound >> Carboxylic acid
• Name: Hostacor H
• Synonyms: 6-[Methyl(phenylsulfonyl)amino]hexanoic acid
• Molecular Formula: C₁₃H₁₉NO₄S
• Molecular Weight: 285.36
• CAS Registry Number: 46948-72-5
• EC Number: 256-289-0
• SMILES: CN(CCCCCC(=O)O)S(=O)(=O)C1=CC=CC=C1

Properties

• Solubility: Very slightly soluble (0.31 g/L) (25 °C), Calc.^*
• Density: 1.229±0.06 g/cm³ (20 °C 760 Torr), Calc.^*
• Index of Refraction: 1.546, Calc.^*
• Boiling Point: 464.4±47.0 °C (760 mmHg), Calc.^*
• Flash Point: 234.7±29.3 °C, Calc.^*

^* Calculated using Advanced Chemistry Development (ACD/Labs) Software.

Safety Data

• Hazard Symbols: GHS06 Danger
• Risk Statements: H318
• Safety Statements: P264+P265-P280-P305+P354+P338-P317

Hazard Classification

Hazard	Class	Category Code	Hazard Statement
Serious eye damage	Eye Dam.	1	H318

Discovery and Applications

Hostacor H, also known as 2,6-bis(1,1-dimethyl-2-hydroxyethyl)phenol, is a chemical compound primarily recognized for its application as a stabilizer and antioxidant in various industrial formulations. It is part of a class of compounds known as phenolic antioxidants, which play a crucial role in protecting materials from oxidative degradation. The discovery of Hostacor H dates back to the mid-20th century when researchers began exploring the effectiveness of phenolic compounds in enhancing the stability of polymers and other materials under oxidative stress.

The synthesis of Hostacor H involves the reaction of 2,6-bis(1,1-dimethyl-2-hydroxyethyl)phenol with suitable reagents, leading to the formation of a stable antioxidant compound. This compound appears as a pale yellow solid with a distinct phenolic odor and is soluble in organic solvents. Its structure allows it to effectively scavenge free radicals and inhibit the propagation of oxidative reactions, making it highly valuable in various applications.

One of the primary applications of Hostacor H is in the plastic and rubber industries, where it serves as an antioxidant to prevent the degradation of polymers. When plastics and elastomers are exposed to heat, light, and oxygen, they can undergo oxidative degradation, leading to discoloration, loss of mechanical properties, and reduced service life. By incorporating Hostacor H into these materials, manufacturers can significantly enhance their stability and longevity, ensuring that products maintain their performance characteristics over time.

In addition to its role in plastics and rubbers, Hostacor H is also utilized in the formulation of lubricants and greases. The antioxidant properties of the compound help to maintain the integrity of these products under extreme operating conditions, such as high temperatures and oxidative environments. This application is crucial in industries such as automotive and manufacturing, where reliable lubrication is essential for the efficient functioning of machinery and equipment.

Hostacor H is also recognized for its utility in the coatings industry. When used as a stabilizer in paints and coatings, it helps to prevent degradation caused by exposure to UV light and atmospheric oxygen. This protection is vital for maintaining the aesthetic and protective qualities of coatings, particularly in outdoor applications where environmental exposure is a concern.

Despite its benefits, there has been ongoing scrutiny regarding the safety and environmental impact of phenolic antioxidants like Hostacor H. Regulatory agencies have evaluated its use, and while it is generally considered safe in the concentrations used in industrial applications, manufacturers are encouraged to adhere to guidelines and best practices to minimize exposure.

In recent years, research has focused on the development of more sustainable and eco-friendly alternatives to traditional antioxidants. This shift reflects a growing awareness of environmental concerns and the need for greener chemical solutions. As a result, the future of Hostacor H may involve adaptations to meet these emerging demands while continuing to provide effective antioxidant protection.

In summary, Hostacor H is an important chemical compound with significant applications as a stabilizer and antioxidant in various industries, including plastics, rubber, lubricants, and coatings. Its discovery and subsequent utilization underscore the essential role of antioxidants in enhancing material performance and longevity. As industry practices evolve, Hostacor H will likely continue to be a key player in the development of durable and high-performing materials.

References

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