Diosmin
[CAS# 520-27-4]

Identification

• Classification: API >> Blood system medication >> Platelet proliferative drug
• Name: Diosmin
• Synonyms: 3',5,7-Trihydroxy-4'-methoxyflavone 7-rutinoside
• Molecular Formula: C₂₈H₃₂O₁₅
• Molecular Weight: 608.54
• CAS Registry Number: 520-27-4
• EC Number: 208-289-7
• SMILES: C[C@H]1[C@@H]([C@H]([C@H]([C@@H](O1)OC[C@@H]2[C@H]([C@@H]([C@H]([C@@H](O2)OC3=CC(=C4C(=C3)OC(=CC4=O)C5=CC(=C(C=C5)OC)O)O)O)O)O)O)O)O

Safety Data

• Hazard Symbols: GHS07 Warning
• Risk Statements: H302-H315-H319-H335
• Safety Statements: P261-P305+P351+P338

Hazard Classification

Hazard	Class	Category Code	Hazard Statement
Germ cell mutagenicity	Muta.	2	H341

Discovery and Applications

Diosmin, a naturally occurring flavonoid glycoside, was discovered in the 1920s as a component of various plants, particularly citrus fruits like oranges and lemons. Its isolation from citrus extracts marked the beginning of its scientific exploration. Diosmin was identified for its potential therapeutic properties and was extensively studied for its pharmacological effects. Researchers found that Diosmin exhibits significant antioxidant, anti-inflammatory, and vascular-protective properties, making it a promising candidate for various medical applications.

Diosmin is primarily used in the treatment of venous disorders, such as chronic venous insufficiency and hemorrhoids. Its ability to strengthen blood vessels, improve microcirculation, and reduce inflammation makes it effective in alleviating symptoms like leg swelling, pain, and discomfort associated with venous insufficiency.

Diosmin, often combined with hesperidin, is utilized in the management of varicose veins. It helps reduce venous distension, improve venous tone, and decrease venous pressure, thereby relieving symptoms and preventing complications associated with varicose veins, such as leg ulcers and thrombosis.

Diosmin has shown promise in the treatment of lymphedema, a condition characterized by swelling due to lymphatic system dysfunction. Its anti-inflammatory and lymphatic drainage-enhancing effects help reduce edema and improve lymphatic circulation, leading to symptom relief and improved quality of life for individuals with lymphedema.

Diosmin, often in combination with hesperidin, is effective in the management of hemorrhoidal disorders. It reduces inflammation, relieves pain, and promotes healing of hemorrhoids by improving venous tone and microcirculation in the anal region.

Due to its vasoprotective and antioxidant properties, Diosmin is beneficial for overall vascular health. It helps prevent vascular damage, improves endothelial function, and reduces oxidative stress, thereby reducing the risk of cardiovascular diseases such as atherosclerosis and hypertension.

Diosmin exhibits potent antioxidant and anti-inflammatory effects, which contribute to its therapeutic benefits in various conditions, including inflammatory bowel disease, diabetic complications, and neurodegenerative disorders.

References

2021. Diosmin in drug design: Computational approaches. Current Computer-Aided Drug Design, 17(3).
DOI: 10.2174/1573409916666200324135734

2017. Diosmin and its antioxidant properties: A review. Oxidative Medicine and Cellular Longevity.
DOI: 10.1155/2017/3281670

2001. Clinical applications of diosmin in vascular disorders. Angiology, 52(Suppl 1).
DOI: 10.1177/0003319701052001s06