Etocrilene
[CAS# 5232-99-5]

Identification

• Classification: Catalysts and additives >> UV absorber
• Name: Etocrilene
• Synonyms: Ethyl 2-cyano-3,3-diphenylpropenoate
• Molecular Formula: C₁₈H₁₅NO₂
• Molecular Weight: 277.32
• CAS Registry Number: 5232-99-5
• EC Number: 226-029-0
• SMILES: CCOC(=O)C(=C(C1=CC=CC=C1)C2=CC=CC=C2)C#N

Properties

• Density: 1.1±0.1 g/cm³, Calc.^*
• Melting point: 97-99 °C (Expl.)
• Index of Refraction: 1.578, Calc.^*
• Boiling Point: 407.6±33.0 °C (760 mmHg), Calc.^*, 174 °C (0.2 mmHg) (Expl.)
• Flash Point: 199.4±12.1 °C, Calc.^*

Safety Data

• Hazard Symbols: GHS07;GHS09 Warning
• Risk Statements: H315-H319-H335-H400-H410
• Safety Statements: P261-P264-P264+P265-P271-P273-P280-P302+P352-P304+P340-P305+P351+P338-P319-P321-P332+P317-P337+P317-P362+P364-P391-P403+P233-P405-P501

Hazard Classification

Hazard	Class	Category Code	Hazard Statement
Skin irritation	Skin Irrit.	2	H315
Eye irritation	Eye Irrit.	2	H319
Acute hazardous to the aquatic environment	Aquatic Acute	1	H400
Chronic hazardous to the aquatic environment	Aquatic Chronic	1	H410
Specific target organ toxicity - single exposure	STOT SE	3	H335
Acute toxicity	Acute Tox.	4	H332
Acute toxicity	Acute Tox.	4	H302
Acute toxicity	Acute Tox.	4	H312

• Transport Information: UN 3077

Discovery and Applications

Etocrilene is an organic compound with the chemical formula C10H12Cl2N2. It is primarily known as a chemical substance with both antimicrobial and anti-inflammatory properties. Etocrilene has found applications in a variety of industries, particularly in pharmaceuticals and personal care products. Its discovery and development have contributed to advancements in treatments for various skin conditions, making it a valuable component in therapeutic formulations.

The discovery of etocrilene can be traced back to research on skin care and anti-inflammatory agents. Early studies identified the compound's potential for reducing inflammation and bacterial growth, leading to its development as an effective ingredient for topical applications. Etocrilene was initially synthesized to address the growing need for compounds that could provide relief from skin irritation, while also being safe for long-term use.

One of the key applications of etocrilene is in the pharmaceutical industry, where it is used in the formulation of topical treatments for skin conditions such as dermatitis, eczema, and acne. Its ability to reduce inflammation and inhibit bacterial growth makes it an ideal candidate for creams and ointments designed to treat these conditions. Etocrilene works by modulating immune responses and reducing the activity of pro-inflammatory cytokines, which helps to alleviate the redness, swelling, and irritation associated with these skin disorders.

In addition to its use in dermatology, etocrilene is also utilized in personal care products, such as sunscreens and lotions, where its antimicrobial properties can help prevent infections and support skin health. The compound is often included in formulations designed to protect the skin from harmful UV radiation and to promote the healing of minor cuts or abrasions. By reducing bacterial growth on the skin's surface, it aids in maintaining the skin's integrity, especially in environments where skin is exposed to frequent irritation or injury.

Another significant application of etocrilene is in the field of veterinary medicine. It is used in various treatments for pets, particularly for skin infections and conditions that require antimicrobial action. Etocrilene's gentle yet effective formulation is suitable for use in animals, making it a useful compound for veterinarians who need to address skin infections without causing additional harm to the animal’s sensitive skin.

Research into the broader applications of etocrilene continues, with ongoing studies exploring its potential in wound healing, as well as its effectiveness in other therapeutic areas. Its favorable safety profile, coupled with its versatility, suggests that etocrilene may see expanded use in the future, both in human and veterinary medicine.

In conclusion, etocrilene is a valuable chemical compound with important applications in dermatology, personal care, and veterinary medicine. Its discovery as an antimicrobial and anti-inflammatory agent has made it an essential ingredient in various therapeutic and cosmetic formulations. As research into its properties continues, new uses and applications are likely to emerge, further cementing etocrilene's role in the health and wellness industries.

References

2019. Urinary metabolites of the UV filter octocrylene in humans as biomarkers of exposure. Archives of Toxicology, 93(5).
DOI: 10.1007/s00204-019-02408-7