Polyanetholesulfonate sodium salt
[CAS# 55963-78-5]

Identification

• Classification: Chemical reagent >> Organic reagent >> Sulfonate / sulfinate
• Name: Polyanetholesulfonate sodium salt
• Synonyms: (E)-1-Methoxy-4-(1-propenyl)benzene homopolymer sulfonated sodium salt
• CAS Registry Number: 55963-78-5 (52993-95-0)
• EC Number: 682-150-2
• SMILES: C/C=C/C1=CC=C(C=C1)OC.[O-]S(=O)[O-].[Na+]

Safety Data

• Hazard Symbols: GHS07 Warning
• Risk Statements: H315-H319-H335
• Safety Statements: P261-P264-P264+P265-P271-P280-P302+P352-P304+P340-P305+P351+P338-P319-P321-P332+P317-P337+P317-P362+P364-P403+P233-P405-P501

Hazard Classification

Hazard	Class	Category Code	Hazard Statement
Skin irritation	Skin Irrit.	2	H315
Eye irritation	Eye Irrit.	2	H319
Specific target organ toxicity - single exposure	STOT SE	3	H335

Discovery and Applications

Polyanethole sulfonate sodium salt, commonly abbreviated as PASS, is a polymer that has attracted attention in various fields due to its unique properties and wide range of applications. The substance has the chemical formula [C_8H_8O_3S]_nNa and features repeating anethole and sulfonate groups, which give it unique functional properties.

Polyanethole sulfonate sodium salt was discovered in the mid-20th century and was initially explored for use as an ion exchange resin and polymer stabilizer. The synthesis of PASS involves the polymerization of anethole, a natural compound derived from fennel, with sulfonic acid groups. The process produces a water-soluble polymer that exhibits high stability and versatility in a variety of chemical environments.

One of the main applications of PASS is in the pharmaceutical field. The compound is used as a stabilizer and excipient in drug formulations to improve the solubility and bioavailability of active pharmaceutical ingredients (APIs). It is valuable in the development of complex drug delivery systems due to its ability to interact with other substances and stabilize formulations. For example, PASS is used to improve the stability of oral and injectable drugs, ensuring their efficacy and shelf life.

In addition to its role in the pharmaceutical sector, PASS is also used in the field of materials science. The unique properties of this polymer make it useful in the development of advanced materials such as films, coatings, and composites. Its ability to modify surface properties and enhance material performance makes it suitable for electronic devices and protective coatings. For example, PASS is used to create thin, flexible films with ideal mechanical and optical properties, aiding innovation in flexible electronics and sensors.

PASS can also be used in environmental science, particularly in water treatment processes. The compound's ion exchange properties allow it to effectively remove pollutants and heavy metals from wastewater. By incorporating PASS into filtration systems, the efficiency of water purification processes can be increased, addressing environmental issues related to water quality and pollution.

The safety profile of PASS is generally favorable, as it is a polymer with low toxicity when used in appropriate concentrations. However, as with any compound, proper handling and safety procedures are essential to prevent any potential risks. The polymer's stability and solubility in water contribute to its safe use in a variety of applications.

References

2015. Sodium polyanethol sulfonate (SPS) falsifies protein staining and quantification and how to solve this problem. Journal of Microbiological Methods, 118.
DOI: 10.1016/j.mimet.2015.10.002

2010. Sodium Polyanethole Sulfonate as an Inhibitor of Activation of Complement Function in Blood Culture Systems. Journal of Clinical Microbiology, 48(3).
DOI: 10.1128/jcm.01985-09

2005. Anticoagulant Carryover May Influence Clot Formation in Direct Tube Coagulase Tests from Blood Cultures. Journal of Clinical Microbiology, 43(9).
DOI: 10.1128/jcm.43.9.4613-4615.2005