Dimethyl sulfite
[CAS# 616-42-2]

Identification

• Classification: Organic raw materials >> Inorganic acid ester
• Name: Dimethyl sulfite
• Synonyms: Methyl sulfite
• Molecular Formula: C₂H₆O₃S
• Molecular Weight: 110.13
• CAS Registry Number: 616-42-2
• EC Number: 210-481-0
• SMILES: COS(=O)OC

Properties

• Density: 1.294
• Boiling point: 126-127 °C
• Refractive index: 1.4085-1.4105
• Flash point: 30 °C
• Water solubility: soluble

Safety Data

• Hazard Symbols: GHS02;GHS07 Warning
• Risk Statements: H226-H315-H319-H335
• Safety Statements: P210-P233-P240-P241-P242-P243-P261-P264-P264+P265-P271-P280-P302+P352-P303+P361+P353-P304+P340-P305+P351+P338-P319-P321-P332+P317-P337+P317-P362+P364-P370+P378-P403+P233-P403+P235-P405-P501

Hazard Classification

Hazard	Class	Category Code	Hazard Statement
Eye irritation	Eye Irrit.	2	H319
Flammable liquids	Flam. Liq.	3	H226
Skin irritation	Skin Irrit.	2	H315
Specific target organ toxicity - single exposure	STOT SE	3	H335

• Transport Information: UN 1993

Discovery and Applications

Dimethyl sulfite is a volatile organic compound with the chemical formula (CH₃O)₂SO₂. It is a colorless liquid with a distinctive odor and is primarily used in chemical synthesis and industrial applications.

Dimethyl sulfite was first synthesized in the early 20th century as chemists explored various sulfur-containing compounds for their unique chemical properties. Its discovery is attributed to research aimed at developing new reagents and intermediates in organic synthesis. The compound is noted for its ability to release sulfur dioxide upon hydrolysis, making it useful in certain chemical reactions.

One of the main applications of dimethyl sulfite is as a methylating agent in organic synthesis. It is employed to introduce methyl groups into molecules, facilitating the formation of methylated products. This property is particularly valuable in the production of pharmaceuticals, agrochemicals, and fine chemicals, where precise modifications to molecular structures are required.

In addition to its role as a methylating agent, dimethyl sulfite is utilized in the production of various sulfur-containing chemicals. It acts as an intermediate in the synthesis of compounds such as sulfonic acids and sulfones, which have applications in detergents, dyes, and pharmaceuticals.

Dimethyl sulfite is also used in the manufacture of antifreeze and as a solvent in certain industrial processes. Its ability to dissolve various substances makes it a versatile solvent in chemical manufacturing and processing.

In environmental science, dimethyl sulfite is studied for its role in atmospheric chemistry. It can contribute to the formation of sulfur dioxide and other sulfur-containing compounds in the atmosphere, which have implications for air quality and climate.

References

2024. Anion-induced electrolyte chemistry enables high energy density primary battery for ultralow-temperature conditions. Science China Chemistry, 67(6).
DOI: 10.1007/s11426-024-2332-y

2020. TriMethylene sulfite as a novel additive for SEI film formation in lithium-ion batteries. Ionics, 26(10).
DOI: 10.1007/s11581-020-03650-1

2017. Thermal and electrochemical properties of poly(butylene sulfite)-based polymer electrolyte. Ionics, 23(12).
DOI: 10.1007/s11581-017-2368-3