Magnesium hydrogen phosphate trihydrate
[CAS# 7782-75-4]

Identification

• Classification: Inorganic chemical industry >> Inorganic salt >> Phosphides, metal phosphoric acid, metaphosphoric acid, hypophosphorous acid and pyrophosphate
• Name: Magnesium hydrogen phosphate trihydrate
• Synonyms: Magnesium phosphate dibasic trihydrate
• Molecular Formula: MgHPO₄.3(H₂O)
• Molecular Weight: 174.33
• CAS Registry Number: 7782-75-4
• EC Number: 616-511-2
• SMILES: O.O.O.OP(=O)([O-])[O-].[Mg+2]

Properties

• Density: 2.13 g/mL

Safety Data

• Hazard Symbols: GHS05 Danger
• Risk Statements: H314-H318
• Safety Statements: P260-P264-P264+P265-P280-P301+P330+P331-P302+P361+P354-P304+P340-P305+P354+P338-P316-P317-P321-P363-P405-P501

Hazard Classification

Hazard	Class	Category Code	Hazard Statement
Skin corrosion	Skin Corr.	1B	H314
Serious eye damage	Eye Dam.	1	H318

Discovery and Applications

Magnesium hydrogen phosphate trihydrate is widely studied and used in the fields of chemistry and materials science due to its unique properties. It consists of magnesium ions (Mg²?), hydrogen phosphate ions (HPO4²?), and water molecules (H2O). The trihydrate form indicates the presence of three water molecules per unit of the compound, which affects its solubility and crystal structure.

In pharmaceutical formulations, magnesium hydrogen phosphate trihydrate is used as an excipient to contribute to the physical properties of tablet and capsule formulations. It can act as a binder, filler, or disintegrant to facilitate the manufacturing process and ensure the stability and bioavailability of the active pharmaceutical ingredient. Magnesium hydrogen phosphate trihydrate is used as an antacid due to its ability to neutralize excess stomach acid. It helps relieve symptoms of heartburn, indigestion, and acid reflux by balancing the pH in the stomach. In addition, its mild laxative properties help relieve constipation.

Magnesium hydrogen phosphate trihydrate is used in the ceramic industry as a precursor for the production of magnesium phosphate ceramics. These ceramics have high thermal stability, chemical resistance, and biocompatibility, making them suitable for biomedical devices, dental materials, and high-temperature insulators.

In biomedical research, magnesium hydrogen phosphate trihydrate has been intensively studied for its potential as a biomaterial. Researchers have explored its biocompatibility and ability to support cell growth and tissue regeneration. It shows promise in applications such as bone scaffolds and drug delivery systems.

Research on magnesium hydrogen phosphate trihydrate continues to expand its use in biomedical materials, ceramics, and pharmaceutical formulations. Future efforts focus on enhancing its properties, developing sustainable production methods, and exploring new applications in biotechnology and environmental remediation.

References

2023. Modulation of struvite composition in full-scale nutrient recovery system using source-separated urine. Water Science and Technology, 88(3).
DOI: 10.2166/wst.2023.254

2024. Research progress on the application of magnesium phosphate bone cement in bone defect repair: A review. Bio-Medical Materials and Engineering, 35(3).
DOI: 10.3233/bme-230164

2024. Injectable biocomposite cement: A dual-setting formula with magnesium potassium phosphate and κ-carrageenan hydrogel for orthopedic advancements. International Journal of Biological Macromolecules
DOI: 10.1016/j.ijbiomac.2024.137922