Tetrahydrolinalool
[CAS# 78-69-3]

Identification

• Classification: Flavors and spices >> Synthetic spice >> Alcoholic spice >> Terpene alcohol
• Name: Tetrahydrolinalool
• Synonyms: 3,7-Dimethyl-3-octanol
• Molecular Formula: C₁₀H₂₂O
• Molecular Weight: 158.28
• CAS Registry Number: 78-69-3 (57706-88-4)
• EC Number: 201-133-9
• FEMA: 3060
• SMILES: CCC(C)(CCCC(C)C)O

Properties

• Density: 0.828
• Boiling point: 193 °C
• Refractive index: 1.431-1.435
• Flash point: 76 °C

Safety Data

• Hazard Symbols: GHS07 Warning
• Risk Statements: H315-H317-H319
• Safety Statements: P261-P264-P264+P265-P272-P280-P302+P352-P305+P351+P338-P321-P332+P317-P333+P317-P337+P317-P362+P364-P501

Hazard Classification

Hazard	Class	Category Code	Hazard Statement
Skin irritation	Skin Irrit.	2	H315
Eye irritation	Eye Irrit.	2	H319
Skin sensitization	Skin Sens.	1B	H317
Eye irritation	Eye Irrit.	2A	H319
Specific target organ toxicity - single exposure	STOT SE	3	H335
Flammable liquids	Flam. Liq.	3	H226

Discovery and Applications

Tetrahydrolinalool, a compound with aromatic properties and multiple uses, is chemically known as 3,7-dimethyloctan-1,6-dien-3-ol and was first synthesized and characterized in the mid-20th century during advances in organic chemistry and perfume research. It is classified as a terpene alcohol and is derived from linalool, a natural compound found in essential oils such as lavender and bergamot, by hydrogenation. This modification enhances its stability and alters its olfactory profile, imparting a softer, rounder fragrance.

The core appeal of tetrahydrolinalool is its delicate floral aroma with hints of citrus and spice. In perfumery, it is a versatile base and modifier that blends harmoniously with a wide range of aromatic compounds to create delicate and long-lasting fragrance compositions. Its ability to enhance and prolong the persistence of fragrances has made it a top choice among perfumers worldwide, contributing to both fine fragrances and everyday personal care products.

In addition to perfumery, tetrahydrolinalool is also widely used in cosmetic and personal care formulations. It adds a light, pleasant scent to skincare, haircare and toiletries without being overpowering. Its mild, hypoallergenic properties make it suitable for sensitive skin types, ensuring compatibility and minimizing the risk of irritation – a key factor in modern cosmetic formulations.

Tetrahydrolinalool has a wide range of uses, not only in premium fragrances and cosmetics, but also in everyday household products. It is a key ingredient in air fresheners, laundry detergents and cleaners, bringing a fresh, clean scent to living spaces and fabrics. Incorporating tetrahydrolinalool into these products enhances the sensory appeal while masking unpleasant odors, thereby enhancing the overall consumer experience.

As with all fragrance ingredients, tetrahydrolinalool must be used in compliance with safety and regulatory requirements. Extensive research and evaluation ensures that tetrahydrolinalool is safe for consumers when used within recommended concentrations and formulations. Regulatory bodies around the world, including the EU and the US, have set strict guidelines to safeguard consumer health and environmental sustainability in fragrance and cosmetic applications.

References

2022. Anxiolytic and Antidepressant-like Effects of Monoterpene Tetrahydrolinalool and In silico Approach of new Potential Targets. Current Topics in Medicinal Chemistry, 22(17).
DOI: 10.2174/1568026622666220505104726

2013. Neurobehavioral and genotoxic evaluation of (-)-linalool in mice. Journal of Natural Medicines, 67(4).
DOI: 10.1007/s11418-013-0751-6