Lily aldehyde
[CAS# 80-54-6]

Identification

• Classification: Organic raw materials >> Aldehyde
• Name: Lily aldehyde
• Synonyms: Lillial; 2-(4-tert-Butylbenzyl)propionaldehyde
• Molecular Formula: C₁₄H₂₀O
• Molecular Weight: 204.31
• CAS Registry Number: 80-54-6
• EC Number: 201-289-8
• SMILES: CC(CC1=CC=C(C=C1)C(C)(C)C)C=O

Properties

• Density: 0.946
• Boiling point: 320.6718 °C (760 mmHg)
• Refractive index: 1.505
• Flash point: 100 °C

Safety Data

• Hazard Symbols: GHS07;GHS08;GHS09 Warning
• Risk Statements: H302-H315-H317-H361-H411
• Safety Statements: P203-P261-P264-P270-P272-P273-P280-P301+P317-P302+P352-P318-P321-P330-P332+P317-P333+P317-P362+P364-P391-P405-P501

Hazard Classification

Hazard	Class	Category Code	Hazard Statement
Acute toxicity	Acute Tox.	4	H302
Skin irritation	Skin Irrit.	2	H315
Chronic hazardous to the aquatic environment	Aquatic Chronic	2	H411
Reproductive toxicity	Repr.	2	H361
Skin sensitization	Skin Sens.	1	H317
Skin sensitization	Skin Sens.	1B	H317
Chronic hazardous to the aquatic environment	Aquatic Chronic	3	H412
Reproductive toxicity	Repr.	1B	H360Fd
Reproductive toxicity	Repr.	1B	H360
Respiratory sensitization	Resp. Sens.	1B	H334
Reproductive toxicity	Repr.	1B	H360FD
Acute toxicity	Acute Tox.	5	H313
Reproductive toxicity	Repr.	1B	H360Fd

• Transport Information: UN 3082

Discovery and Applications

Lilium aldehyde, chemically known as 2-methyl-3-phenylpropanal, was first synthesized and isolated in the early 20th century as the result of a sustained effort to replicate the scent of lilies. Inspired by the natural essence of lilies, chemists sought to capture and reproduce their unique floral aroma through organic synthesis. The discovery of lilium aldehyde marked a major advance in perfume chemistry and paved the way for its widespread use in perfumery. Structurally, lilium aldehyde features a benzene ring, a propanal side chain, and a methyl substituent, giving off a rich and complex floral scent reminiscent of fresh lilies in bloom. This aromatic profile lends itself well to perfumery, where lilium aldehyde is a key ingredient in creating bouquets and enhancing fragrance compositions. Reminiscent of the natural aroma of lilies, it adds depth and sophistication to perfumes and colognes, satisfying a wide range of olfactory preferences.

In the perfume world, lilium aldehyde is highly regarded as a floral top note, adding freshness and elegance to perfumes. It blends harmoniously with other floral, fruity, and woody notes to create complex and balanced scents that evoke emotions and memories. The addition of lily aldehyde can extend the durability and diffusion of fragrances, ensuring that the user and those around them have an unforgettable olfactory experience.

In addition to perfumes, lily aldehyde can also be used in cosmetics and personal care products, where its floral scent enhances the sensory appeal of skin care, hair care and bath products. Incorporating it into lotions, creams and soaps can add a touch of luxury and sophistication to these products, satisfying consumers' preference for an elegant and luxurious experience in their daily grooming rituals.

The versatility of lily aldehyde is not limited to personal care, but also extends to industrial applications, where it can be used as a fragrance enhancer in air fresheners, detergents and household cleaners. It can mask odors and emit a pleasant floral scent, promoting cleanliness and freshness in home and commercial environments, enhancing the overall sensory experience of users.

References

2023. Toxicological investigation of lilial. Scientific Reports, 13(1).
DOI: 10.1038/s41598-023-45598-y

2023. Hidden threat lurking in extensive hand hygiene during the Covid-19 pandemic: investigation of sensitizing molecules in gel products by hyphenated chromatography techniques. Analytical and Bioanalytical Chemistry, 415(18).
DOI: 10.1007/s00216-023-04714-7