Cerin
[CAS# 8001-75-0]

Identification

• Classification: Natural product >> Terpenes
• Name: Cerin
• Synonyms: (2R,4R,4aS,6aS,6aS,6bR,8aR,12aR,14aS,14bS)-2-hydroxy-4,4a,6a,6b,8a,11,11,14a-octamethyl-2,4,5,6,6a,7,8,9,10,12,12a,13,14,14b-tetradecahydro-1H-picen-3-one
• Molecular Formula: C₃₀H₅₀O₂
• Molecular Weight: 442.72
• CAS Registry Number: 8001-75-0
• EC Number: 232-290-1
• SMILES: C[C@H]1C(=O)[C@@H](C[C@@H]2[C@@]1(CC[C@H]3[C@]2(CC[C@@]4([C@@]3(CC[C@@]5([C@H]4CC(CC5)(C)C)C)C)C)C)C)O

Properties

• Density: 1.0±0.1 g/cm³, Calc.^*
• Index of Refraction: 1.514, Calc.^*
• Boiling Point: 510.1±33.0 °C (760 mmHg), Calc.^*
• Flash Point: 215.9±18.0 °C, Calc.^*

^* Calculated using Advanced Chemistry Development (ACD/Labs) Software.

Safety Data

• Hazard Symbols: GHS07 Warning
• Risk Statements: H335
• Safety Statements: P202-P235-P262-P264

Discovery and Applications

Cerin is a triterpenoid compound found in various plant sources, including the bark of Quercus species (oak trees) and the leaves of certain medicinal plants. This naturally occurring compound, also known as betulinic acid lactone, has drawn scientific interest due to its unique structure and bioactive properties. The discovery of cerin can be traced back to the study of traditional herbal remedies, where extracts from oak and related plants were historically used for their medicinal properties. Chemists in the 20th century succeeded in isolating cerin, allowing for detailed studies of its structure and bioactivity.

One of the primary applications of cerin is in pharmacology, where its biological properties have shown potential in therapeutic development. Studies indicate that cerin possesses anti-inflammatory properties, which make it a candidate for treatments targeting inflammation-related diseases, such as arthritis and certain cardiovascular conditions. Its ability to modulate immune responses may also play a role in its anti-inflammatory effects, highlighting its potential as a natural alternative for managing inflammatory conditions.

Cerin has also demonstrated anticancer properties in various in vitro studies. It appears to inhibit cancer cell growth and induce apoptosis (programmed cell death) in certain tumor cell lines. This has led to interest in cerin as a natural compound for cancer research and potential therapies. Researchers continue to investigate its mechanisms of action, focusing on how it interacts with cellular pathways involved in cell survival and apoptosis.

In addition to its medicinal potential, cerin is recognized for its antioxidant properties, which have implications in both health and the cosmetics industry. Its antioxidant activity helps neutralize free radicals, preventing oxidative stress and cellular damage. This protective effect makes cerin a valuable ingredient in skincare products, particularly those aimed at reducing the effects of aging and environmental stress on the skin.

Beyond healthcare and cosmetics, cerin’s applications are extending into the food industry as a natural preservative. Due to its antioxidative properties, cerin can enhance food stability by preventing lipid peroxidation, which prolongs shelf life and preserves quality. The trend toward natural food additives aligns well with cerin’s profile, as consumers increasingly seek products with fewer synthetic preservatives.

In conclusion, cerin is a notable triterpenoid with a wide range of applications across multiple industries. From its roots in traditional medicine to its modern uses in pharmaceuticals, cosmetics, and food preservation, cerin demonstrates the potential of natural compounds in promoting health and sustainability. Ongoing research into cerin’s bioactivity continues to reveal new possibilities for its use, making it a valuable natural resource with expanding relevance in today’s health and wellness industries.

References

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