Strontium citrate
[CAS# 813-97-8]

Identification

• Classification: Organic raw materials >> Organometallic salt
• Name: Strontium citrate
• Synonyms: Strontium 2-hydroxy-1,2,3-propanetricarboxylate; Tristrontium dicitrate
• Molecular Formula: C₆H₆O₇Sr
• Molecular Weight: 277.73
• CAS Registry Number: 813-97-8
• EC Number: 212-392-2
• SMILES: C(C(=O)[O-])C(CC(=O)[O-])(C(=O)O)O.[Sr+2]

Discovery and Applications

Strontium citrate, a compound formed by the reaction of strontium salts with citric acid, was first synthesized in the late 20th century as interest in the potential benefits of strontium for bone health grew. Strontium itself was discovered in the early 1800s by Scottish chemist William Cruickshank, who found it in mineral samples from the town of Stroentian, Scotland. The formulation of strontium citrate came about as researchers sought a more bioavailable form of strontium for therapeutic use, particularly in bone health care.

Strontium citrate is primarily used to support bone health and treat osteoporosis. It is thought to increase bone density by stimulating bone formation and inhibiting bone resorption. Clinical studies have shown that supplementation with strontium citrate increases bone mineral density, making it a powerful tool for treating osteoporosis and reducing the risk of fractures.

As a dietary supplement, strontium citrate is marketed for its potential to improve bone health and support bone strength. It is often combined with other bone-supporting nutrients, such as calcium and vitamin D, to provide a comprehensive approach to bone care. Its bioavailability makes it a preferred choice for some supplements compared to other forms of strontium, such as strontium ranelate.

In clinical settings, strontium citrate is used as part of an osteoporosis management strategy. It is often recommended for patients who are at high risk for fracture or who have not responded well to other treatments. The compound's effects in promoting bone density and reducing fracture risk make it an important consideration in osteoporosis treatment options.

Ongoing strontium citrate research continues to explore its benefits and mechanisms of action. Studies are investigating its effects on bone metabolism, interactions with other nutrients, and long-term safety. This research aims to further validate its efficacy and optimize its use in bone health management.

Strontium citrate is also being explored for use in veterinary medicine, particularly in managing bone health in animals. It has potential applications in treating bone-related diseases, supporting overall bone health, and recovery after injury in livestock and pets.

References

2018. The Chemical and Products Database, a resource for exposure-relevant data on chemicals in consumer products. Scientific Data, 5.
DOI: 10.1038/sdata.2018.125