Vanillyl butyl ether
[CAS# 82654-98-6]

Identification

• Classification: Flavors and spices
• Name: Vanillyl butyl ether
• Synonyms: 4-(butoxymethyl)-2-methoxyphenol
• Molecular Formula: C₁₂H₁₈O₃
• Molecular Weight: 210.27
• CAS Registry Number: 82654-98-6
• EC Number: 444-010-7
• FEMA: 3796
• SMILES: CCCCOCC1=CC(=C(C=C1)O)OC

Properties

• Density: 1.057
• Boiling point: 241 °C
• Refractive index: 1.516
• Flash point: 113 °C

Safety Data

• Hazard Symbols: GHS07 Warning
• Risk Statements: H317-H319
• Safety Statements: P261-P264+P265-P272-P280-P302+P352-P305+P351+P338-P321-P333+P317-P337+P317-P362+P364-P501

Hazard Classification

Hazard	Class	Category Code	Hazard Statement
Skin sensitization	Skin Sens.	1B	H317
Eye irritation	Eye Irrit.	2	H319
Chronic hazardous to the aquatic environment	Aquatic Chronic	3	H412
Skin sensitization	Skin Sens.	1	H317
Skin irritation	Skin Irrit.	2	H315
Eye irritation	Eye Irrit.	2A	H319

Discovery and Applications

Vanillyl butyl ether (VBE) was discovered in the mid-20th century as researchers explored new compounds derived from vanillin, a primary component of vanilla bean extract. VBE, with the molecular formula C12H18O3, is synthesized by etherifying vanillin with butanol. VBE's ability to induce a warming sensation on the skin, along with its pleasant aroma, quickly made it a valuable ingredient in cosmetics and personal care products.

VBE is extensively used in the cosmetics and personal care industry for its gentle warming sensation on the skin. This makes it a popular ingredient in products such as warming creams, lotions, and massage oils. VBE is also included in lip plumping products, where it enhances blood circulation to the lips, creating a fuller appearance.

In topical pain relief formulations, VBE serves as a mild counter-irritant, providing a soothing warmth that helps alleviate minor muscle and joint discomfort. It is used in creams, gels, and patches designed to offer relief from pain associated with arthritis, sprains, and other musculoskeletal conditions.

VBE is also utilized in hair care products, such as shampoos and conditioners, for its stimulating effect on the scalp. The warming sensation can help increase blood flow to the hair follicles, potentially promoting healthier hair growth.

In the field of aromatherapy, VBE is used for its calming and soothing properties. Its mild, vanilla-like fragrance contributes to a relaxing atmosphere when used in diffusers, candles, and massage oils.

Though less common, VBE is sometimes used as a flavoring agent in food and beverage products. Its vanilla-like aroma and the mild warming sensation can enhance the sensory profile of various consumables. However, its use in food is typically limited and subject to regulatory approval, ensuring safety and appropriate dosage levels.

References

2015. Reciprocal effects of capsaicin and menthol on thermosensation through regulated activities of TRPV1 and TRPM8. The journal of physiological sciences : JPS, 66(5).
DOI: 10.1007/s12576-015-0427-y