3-Chloro-2-pyrazinemethanamine hydrochloride
[CAS# 939412-86-9]

Identification

• Classification: Pharmaceutical intermediate >> Heterocyclic compound intermediate >> Pyrazines
• Name: 3-Chloro-2-pyrazinemethanamine hydrochloride
• Synonyms: (3-Chloropyrazin-2-yl)methanamine hydrochloride
• Molecular Formula: C₅H₆ClN₃.HCl
• Molecular Weight: 180.03
• CAS Registry Number: 939412-86-9
• EC Number: 686-960-7
• SMILES: C1=CN=C(C(=N1)CN)Cl.Cl

Safety Data

• Hazard Symbols: GHS05;GHS07 Danger
• Risk Statements: H302-H318
• Safety Statements: P264-P264+P265-P270-P280-P301+P317-P305+P354+P338-P317-P330-P501

Hazard Classification

Hazard	Class	Category Code	Hazard Statement
Acute toxicity	Acute Tox.	4	H302
Serious eye damage	Eye Dam.	1	H318
Skin irritation	Skin Irrit.	2	H315
Eye irritation	Eye Irrit.	2A	H319
Specific target organ toxicity - single exposure	STOT SE	3	H335

Discovery and Applications

3-Chloro-2-pyrazinemethylamine hydrochloride is a compound with important applications in drug discovery and development, synthesized by chlorination of 2-pyrazinemethylamine under controlled conditions. The synthesis of this compound marks a milestone in heterocyclic chemistry, providing a route to chlorinated pyrazine derivatives with unique chemical properties.

The molecular structure of 3-chloro-2-pyrazinemethylamine hydrochloride includes a pyrazine ring with a chlorine substituent at the 3-position, and an amino group connected to a methylene bridge. This arrangement gives it specific chemical properties, such as solubility in water and organic solvents, stability under standard laboratory conditions, and the possibility of further functionalization.

In pharmaceuticals, 3-chloro-2-pyrazinemethylamine hydrochloride is a valuable intermediate for the synthesis of biologically active compounds. Its structural features allow modifications to improve drug efficacy, bioavailability, and selectivity against specific disease targets. Researchers explore derivatives of this compound in drug discovery programs, focusing on antibacterial agents, antivirals, and potential treatments for neurological diseases.

In chemistry, 3-chloro-2-pyrazinemethylamine hydrochloride is used as a building block in organic synthesis. Its reactivity enables the introduction of different functional groups, thus facilitating the creation of complex molecules and pharmaceutical intermediates. It is a versatile precursor for the synthesis of fine chemicals, agrochemicals, and specialty materials for various industrial applications.

In biological and biomedical research, 3-chloro-2-pyrazinemethylamine hydrochloride derivatives are investigated for their pharmacological activities and potential therapeutic benefits. Research focuses on understanding their mechanisms of action, metabolic pathways, and interactions with biological systems. This research contributes to improved knowledge in drug metabolism, pharmacokinetics, and drug interactions, which is essential for the development of safe and effective drugs.

Current research on 3-chloro-2-pyrazinemethylamine hydrochloride is aimed at exploring its applications in personalized medicine, nanotechnology, and targeted drug delivery systems. The focus is on optimizing synthetic methods, expanding its pharmacological properties, and exploring new formulations to address emerging healthcare challenges.

References

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